Using remote ischemic conditioning to improve cognitive function in older adults
Chronic Remote Ischemic Conditioning in Vascular Cognitive Impairment: A Dose Escalation Study
NA · Augusta University · NCT06179797
This study is testing if a new treatment called remote ischemic conditioning can help improve thinking skills in older adults with changes in their brain related to aging.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 56 Years and up |
| Sex | All |
| Sponsor | Augusta University (other) |
| Locations | 1 site (Augusta, Georgia) |
| Trial ID | NCT06179797 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effects of remote ischemic conditioning (RIC) on blood biomarkers in patients with age-related cerebral white matter changes. It aims to determine the dose-response relationship of RIC in a group of 40 participants aged 55 and older. The study will also assess the tolerability and adherence to the treatment protocol, preparing for a larger efficacy trial in the future. Participants will undergo daily RIC sessions while their biomarker levels are monitored.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 55 and older with moderate age-related cerebral white matter changes as indicated by MRI.
Not a fit: Patients with prior non-lacunar strokes or those unable to cooperate with the conditioning device may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved cognitive function and better management of vascular cognitive impairment in older adults.
How similar studies have performed: While this approach is novel in the context of vascular cognitive impairment, similar studies on remote ischemic conditioning have shown promising results in other conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥55 years 2. Head MRI in the past 6 months showing no more than moderate age related cerebral white matter changes (Fazekas score 0-2). 3. Able to walk without assistance \& independently perform basic activities of daily living. 4. Able to understand this study and agree for a valid consent. Exclusion Criteria: Prior non-lacunar (cortical) stroke. 2. Unable to cooperate with the use of the conditioning device. 3. Confounding illness that might interfere with the interpretation of results (such as active malignancy or multiple sclerosis). 4. Contraindication to transient arm ischemia in either arm (such as symptomatic peripheral artery disease).
Where this trial is running
Augusta, Georgia
- Wellstar MCG Health — Augusta, Georgia, United States (RECRUITING)
Study contacts
- Study coordinator: Askiel Bruno, MD
- Email: abruno@augusta.edu
- Phone: 706-721-1691
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Age-related Cerebral White Matter Changes, Cognition Disorder