Using Remimazolam to Reduce Postoperative Atrial Fibrillation in Heart Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of remimazolam, a newly approved sedative with anti-inflammatory properties, in reducing the incidence of postoperative atrial fibrillation (POAF) in patients undergoing coronary artery bypass grafting (CABG). The study will enroll 50 patients, who will be randomly assigned to receive either remimazolam or a control treatment. Blood levels of inflammatory markers, stress hormones, and myocardial injury indicators will be measured to assess the drug's impact. This pilot study aims to gather data for a larger double-blind randomized controlled trial.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 50-70 years old;
* BMI 18-28 kg/m2；
* Selective CABG surgery will be performed at the Yangzhou Institute Heart and Great Vessels, the Affiliated Hospital of Yangzhou University, Yangzhou, China.
* Patients agree to participate in this study and sign the informed consent form.

Exclusion Criteria:

* Emergency surgery;
* with any other type of cardiac surgery;
* pre-operative supraventricular arrhythmia;
* with moderate or severe valve disease before surgery;
* with a history of chemotherapy or radiotherapy;
* with a history of thoracic or cardiovascular surgery;
* diuretics usage before the surgery.

Where it's running

• The Affiliated Hospital of Yangzhou University.
  Yangzhou, Jiangsu, China Recruiting

Study contacts

• Study coordinator: Xiaojun He, MD, Ph.D.
• Email: xhe34baltimore@163.com
• Phone: +86-13524954567

Similar studies

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.