Using REBOA for nontraumatic cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter randomized controlled trial aims to evaluate the clinical effects of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) in patients experiencing nontraumatic out-of-hospital cardiac arrest (OHCA). Eligible patients aged 20 to 80 will be randomized into two groups: one receiving conventional advanced cardiopulmonary life support (ACLS) and the other receiving ACLS with REBOA application. The study will take place in South Korea and Taiwan, focusing on improving coronary and brain perfusion during resuscitation efforts. The trial will assess the effectiveness of REBOA in enhancing patient outcomes compared to standard care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult nontraumatic OHCA
* Witnessed arrest
* Arrival at ER from 9AM to 5PM (in South Korea) and 8AM to 8PM (in Taiwan)

Exclusion Criteria:

1. age below 20 years old or over 80 years old,
2. traumatic cardiac arrest,
3. those with unwitnessed cardiac arrest,
4. pregnant patients,
5. patients who have already achieved ROSC upon arrival at the emergency department
6. pre-cardiac arrest cerebral performance category of 3-4
7. those showing evidence of cardiac arrest due to bleeding (such as gastrointestinal bleeding)
8. those suspected of having aortic disease, such as dissection, intramural hematoma, or aneurysm, by bedside ultrasound performed immediately after ED arrival or have a previous history of aortic disease
9. whose legal representative has requested termination of resuscitation efforts before study enrollment
10. declared dead at scene before randomization
11. Patients who meet the criteria for extracorporeal cardiopulmonary resuscitation (ECPR), and therefore the decision is made to perform ECPR, will not be enrolled. The ECPR criteria applies when all of the following criteria are met: pre-cardiac arrest CPC of 1-2, witnessed cardiac arrest with bystander CPR, ages between 20-70, initial shockable rhythm, ECMO pump-on available within 60 minutes of onset of cardiac arrest, and patients without end-stage diseases such as cancer, liver cirrhosis, or end-stage renal failure.

Where it's running

• Seoul National Univeristy Bundang Hospital
  Seongnam-si, Gyeonggi-do, South Korea Recruiting

Study contacts

• Study coordinator: Hee Eun Kim
• Email: hekim9111@gmail.com
• Phone: 82-31-787-7579

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• NEURESCUE aortic balloon catheter added to advanced cardiac life support

  This trial will test whether adding the NEURESCUE aortic balloon catheter to standard advanced cardiac life support helps adults (18–80) with witnessed cardiac arrest and non-shockable rhythms achieve return of spontaneous circulation and better outcomes.

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• Two-way video support for paramedics caring for infants with life-threatening breathing problems.

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• Evaluating pediatric resuscitation quality across multiple centers

  This study is testing how different techniques of chest compressions during CPR can improve survival and brain health for children who have a cardiac arrest.

  Recruiting at 61 sites Children's Hospital of Philadelphia · Los Angeles, California and 62 other locations · NCT02708134

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.