Using realSKIN® for complete wound closure of burn wounds instead of skin grafts

A Phase III Open-Label, Multicenter, Randomized, Controlled Clinical Trial to Evaluate the Safety and Efficacy of realSKIN® to Provide Complete Wound Closure of Mixed-Depth, Full-Thickness Burn Wounds as an Alternative to Autografting

This study is testing if realSKIN®, a new skin treatment, can help heal severe burn wounds better than traditional skin grafts in adults who need surgery.

Quick facts

• Phase: PHASE3
• Study type: Interventional
• Enrollment: 50 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: XenoTherapeutics, Inc. (other)
• Drugs / interventions: chemotherapy, radiation, prednisone
• Locations: 4 sites (Phoenix, Arizona and 3 other locations)
• Trial ID: NCT06223269 on ClinicalTrials.gov

What this trial studies

This Phase 3 clinical trial evaluates the safety and efficacy of realSKIN®, a skin xenotransplant, as an alternative to autografting for treating severe mixed-depth and full-thickness burn wounds. The study involves approximately 50 participants aged 18 and older who have burn wounds requiring surgical intervention. Each participant will receive both realSKIN® and autografting at different wound sites, allowing for a direct comparison within the same individual. The goal is to determine if realSKIN® can achieve complete and durable wound closure effectively.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with severe mixed-depth and full-thickness thermal burn wounds covering less than 50% of their total body surface area.

Not a fit: Patients with burn wounds that do not require surgical intervention or those with total body surface area burns exceeding 50% may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could provide a less invasive and more effective treatment option for patients with severe burn injuries.

How similar studies have performed: Other studies have explored skin xenotransplants, but this specific approach using realSKIN® as an alternative to autografting is novel.

Eligibility criteria

Inclusion Criteria:

1. The subject, or the subject's legally authorized representative (LAR), provides written informed consent to participate in this study
2. Males or females age greater than or equal to 18 years old
3. Total Burn Surface Area (TBSA) \<50% to include mixed depth and full-thickness burn wounds as defined as "primarily full-thickness (FT) and deep-partial (DPT) thermal burns (e.g. \>60% of the total burn area should be FT and DPT) before debridement", and full-thickness burns for which surgical intervention is clinically indicated
4. Having a mixed depth thermal burn wound including full thickness requiring skin grafting
5. Biological females must have a negative serum pregnancy test at Screening and must not be nursing
6. All subjects must agree to use a protocol-approved method of contraception for a minimum of 3 months following realSKIN placement, which includes a barrier method plus one or more of the following:

   * Hormonal contraceptives (e.g., birth control pills, skin patches, vaginal rings, and the Depo-Provera shot)
   * Intrauterine device (IUD)
   * Male or female condoms with spermicide
   * Diaphragm with spermicide
   * Permanent tubal occlusive birth control system
7. Sufficient area of burn wound for realSKIN and comparator autograft placement to not be located on face or hands or having a target graft site centered on high-impact areas such as joints, weight-bearing areas (e.g. soles of feet), or the inguinal region, per Investigator's judgment

Exclusion Criteria:

1. Pregnant or lactating women
2. Documented history of infection with human immunodeficiency virus (HIV) or other condition(s) that in the opinion of the Investigator may compromise patient safety or study objectives
3. Immunosuppressive medication regimens e.g. antineoplastics, high dose steroids (\>10 mg prednisone/day), TNF alpha inhibitors, calcineurin inhibitors (cyclosporine, tacrolimus), anti- proliferative agents, and other immunomodulators
4. Active malignancy, including those requiring surgery, chemotherapy, and/or radiation in the past 5 years; non-metastatic basal or squamous cell carcinoma of the skin and cervical carcinoma in situ are allowed
5. Use of any experimental or investigational drugs within 30 days prior to placement of realSKIN
6. Previously received a porcine or other xenogeneic tissue product, including but not limited to: glutaraldehyde fixed porcine or bovine bioprosthetic heart valve replacements and glutaraldehyde fixed porcine dermal matrix (e.g., EZ Derm)
7. Patients with advanced or unstable/uncontrolled comorbid conditions, such as advanced renal disease, diabetes mellitus and liver disease
8. Patients with HbA1c ≥ 10.0%; specimen must be obtained for screening purposes if current (within past 3 months) value is not available
9. Patients with a history of chronic end stage renal disease defined as MDRD CrCL \< 15mL/min or receiving chronic dialysis
10. Patients with a history of chronic liver disease or cirrhosis (Child-Pugh Score C); evidence of acute or chronic hepatitis B infection based on documented HBV serology testing
11. Known documented history of Hepatitis B, Hepatitis C, Treponema pallidum, Cytomegalovirus, herpes or varicella zoster; note: Successfully treated hepatitis C patients without evidence of end stage liver disease is allowed; if HCV antibody reactive, then HCV RNA must be undetectable
12. Recent (within 3 months prior to study enrollment) MI, unstable angina leading to hospitalization, uncontrolled, CABG, PCI, carotid surgery or stenting, cerebrovascular accident, transient ischemic attack, endovascular procedure, or surgical intervention for peripheral vascular disease or plans to undergo a major surgical or interventional procedure (e.g., PCI, CABG, carotid or peripheral revascularization)
13. Presence of venous or arterial vascular disorder directly affecting the area of burn wound
14. Pre-existing haemolytic anemia
15. Chronic malnourishment as determined by Investigator
16. Inhalation injury as determined by bronchoscopic exam if available, or diagnosis at the time of screening
17. Systemic anticoagulation at the time of treatment or INR \> 2
18. Documented evidence of wound infection at Screening
19. Evidence of sepsis at Screening

Where this trial is running

Phoenix, Arizona and 3 other locations

• Arizona Burn Center Valleywise Health — Phoenix, Arizona, United States (RECRUITING)
• JMS Burn Center at Doctors Hospital — Augusta, Georgia, United States (RECRUITING)
• MaineHealth Maine Medical Center — Portland, Maine, United States (NOT_YET_RECRUITING)
• Massachusetts General Hospital — Boston, Massachusetts, United States (NOT_YET_RECRUITING)

Study contacts

• Principal investigator: Bounthavy Homsombath, MD — JMS BURN CENTER AT DOCTORS HOSPITAL OF AUGUSTA
• Study coordinator: Jon Adkins, MBA

Conditions: Burns Degree Third, Burn, Burn Degree Second, Thermal Burn, Wound Heal, Full-thickness Burn, Complete Wound Closure, Durable Wound Closure