Using PSMA and FAPI PET scans to map salivary gland function and inflammation in Sjögren's syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center study will perform paired 68Ga-PSMA PET/CT and 68Ga-FAPI PET/CT scans in adults with primary Sjögren's syndrome and a comparison group of patients scheduled for FAPI imaging for solid tumors. PSMA uptake is expected to reflect salivary acinar cell function while FAPI uptake highlights activated fibroblasts and fibroblast-driven remodeling; the investigators will compare tracer signals within the same glands. They will derive a combined PSMA/FAPI Index to map a function–inflammation spectrum and examine correlations between the two tracers and clinical disease features. Imaging results will be analyzed to explore whether this noninvasive paired biomarker can improve staging and monitoring of pSS.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-80 years;
* Fulfillment of the 2016 ACR-EULAR Classification Criteria for pSS at enrollment. OR diagnosis of a solid tumor scheduled for FAPI PET imaging

Exclusion Criteria:

* Combined with tumors or other connective tissue diseases (for SS group);
* Patients who are currently using hormones/biological agents (for both groups)；
* Pregnancy or lactation

Where it's running

• Peking Union Medical College Hospital
  Beijing, China Recruiting

Study contacts

• Study coordinator: Zhaohui Zhu, MD
• Email: 13611093752@163.com
• Phone: 13611093752

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.