Using PRP to Improve Endometrial Thickness in Women with Infertility
Effect of Autologous Platelet Rich Plasma(a-PRP) Intrauterine Instillation in Infertile Women With Thin Endometrium in Frozen-thawed Embryo Transfer Cycle: a Randomized Controlled Study
This study tests if using a treatment called platelet-rich plasma (PRP) can help women with infertility and thin uterine lining have a thicker endometrium to improve their chances of getting pregnant.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 36 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | Mahidol University Academic / other |
| Locations | 1 site (Bangkok Noi, Bangkok) |
| Trial ID | NCT06234540 on ClinicalTrials.gov |
What this trial studies
This study compares the effects of intrauterine instillation of autologous platelet-rich plasma (PRP) versus no treatment on endometrial thickness in infertile women with a history of thin endometrium. The focus is on women who have previously experienced cycle cancellations due to endometrial thickness less than 7 mm during IVF/ICSI procedures. The goal is to determine if PRP can enhance the uterine lining and improve the chances of successful embryo implantation during frozen-thaw cycles. The study is conducted at Siriraj Hospital in Bangkok, Thailand.
Who should consider this trial
Good fit: Ideal candidates are Thai women over 18 years old who have a history of IVF cycle cancellation due to thin endometrium.
Not a fit: Patients with medical conditions affecting platelet function or those with uterine anomalies may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve pregnancy rates for women with thin endometrium undergoing IVF.
How similar studies have performed: Previous studies have shown promising results using PRP to increase endometrial thickness, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who will undergo frozen embryo transfer (Frozen-thawed cycle) * Age above 18 years * Thai nationality * Have a history of cycle cancellation due to a thin endometrium \<7 mm. after standard hormonal treatmetn Exclusion Criteria: * medical conditions eg. Platelet dysfunction , vWD * thrombocytopenia \<100,000 cell/mm3 * Receive antiplatelet therapy * Uterine anomaly, cavity distortion eg submucous myoma uteri, uterine synergia, endometrial polyp
Where this trial is running
Bangkok Noi, Bangkok
- Siriraj Hospital — Bangkok Noi, Bangkok, Thailand (Recruiting)
Study contacts
- Principal investigator: Sootthinan Pothisan — Mahidol University
- Study coordinator: Sootthinan Pothisan
- Email: sootthinan.pot@gmail.com
- Phone: 0894600852
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.