Using PRP injections to treat shoulder osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of platelet-rich plasma (PRP) injections in treating glenohumeral osteoarthritis by comparing low-dose and high-dose PRP preparations against a saline control. Participants aged 18-100 with significant shoulder pain due to osteoarthritis will receive one of the three treatments after failing conservative therapies. The study aims to determine which PRP dosage provides better outcomes for patients suffering from this condition. MRI confirmation of joint issues and a history of pain are required for eligibility.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18-100 years old
* Average NRS pain greater than or equal to 5/10 as a direct result of glenohumeral osteoarthritis (any severity: mild, moderate, or severe) and/or chondral lesion or loss
* At least 3 months of pain after onset of symptoms that has failed conservative treatments, including physical therapy
* MRI of the affected joint
* Transient relief of symptoms after a diagnostic intra-articular injection into the joint
* Email address or network access

Exclusion Criteria:

* Inability to hold non-steroidal anti-inflammatory drugs for 2 weeks prior and 1 month after the injection
* Prior platelet-rich plasma injection
* Steroid injection within 3 months of the initial injection
* Hyaluronic acid within 6 months of the initial injection
* Involved in workers' compensation or active litigation involving the affected joint
* History of Plavix use
* Known uncontrolled systemic illness (uncontrolled diabetes, HIV, vasculitis, autoimmune/autoinflammatory disease)
* Presence of acute fractures or gross mechanical deformities
* Concurrent "uncontrolled" cervical disorders

Where it's running

• Hospital for Special Surgery
  New York, New York, United States Recruiting

Study contacts

• Study coordinator: Jonathan Kirschner, MD
• Email: kirschnerj@hss.edu
• Phone: 646-714-6327

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.