Using propofol for anesthesia in liver transplant surgery
Effect of Isoflurane and Target Control Infusion (TCI) Propofol on Intra-operative Usage of Vasopressors in Liver Transplant Recipients: A Randomized Controlled Trial.
This study is testing whether using propofol instead of isoflurane for anesthesia during liver transplant surgery can lead to better heart and kidney function after the operation.
Quick facts
| Phase | Phase2; Phase3 |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 99 Years |
| Sex | All |
| Sponsor | Institute of Liver and Biliary Sciences, India Academic / other |
| Locations | 1 site (Delhi) |
| Trial ID | NCT06418893 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of target-controlled infusion (TCI) propofol compared to isoflurane on intraoperative hemodynamics and postoperative liver and kidney functions in patients undergoing living donor liver transplants. The research aims to determine whether propofol's antioxidant properties can provide better outcomes in terms of organ protection during surgery. By analyzing the hemodynamic stability and recovery profiles associated with each anesthetic agent, the study seeks to enhance patient care in liver transplant procedures.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old who are scheduled for a living donor liver transplant.
Not a fit: Patients with acute liver failure, pre-existing cardiac or renal dysfunction, or allergies to propofol will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved postoperative recovery and organ function in liver transplant recipients.
How similar studies have performed: While there is limited research directly comparing propofol and isoflurane in this specific context, the use of propofol has shown promise in other surgical settings, suggesting potential benefits.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria:-Above 18 years of age who will undergo living donor liver transplant - Exclusion Criteria: Refusal to consent * Acute liver failure, Acute on chronic liver failure * Allergic to propofol or any component of propofol * Patients with pre existing cardiac dysfunction and cardiomyopathy * Patients with pre existing renal dysfunction/ deranged RFTs preoperatively
Where this trial is running
Delhi
- Institute of liver and biliary sciences — Delhi, India (Recruiting)
Study contacts
- Study coordinator: Abhinav Sharma, MD
- Email: abhi27sh@gmail.com
- Phone: 8860790151
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.