Using probiotics with antibiotics to prevent bacterial vaginosis recurrence

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of combining oral probiotics (Umeta-mimi) with Metronidazole vaginal suppositories in preventing the recurrence of bacterial vaginosis (BV). Participants will receive the probiotics for 30 days alongside a 7-day course of Metronidazole. The study will also analyze the relationship between vaginal and intestinal microbiota through metagenomic assessments at various time points. The goal is to determine if this combined treatment is superior to using Metronidazole alone.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Aged 18 to 55 years old, with history of sexual activity,
2. Amsel criterion for diagnosing BV
3. Sign informed consent

Exclusion Criteria:

1. History of systemic organic diseases or psychiatric diseases
2. Planning for or during pregnancy, lactation, menstruation
3. within 5 days of onset of the disease, any antibiotics has been used
4. Long-term use of contraceptives or immunosuppressant
5. Anaphylactic constitution or allergic to known ingredients of research drugs
6. No same fixed partner (RSP) before and after treatment

Where it's running

• Peking University Shenzhen Hosptal
  Shenzhen, Guangdong, China Recruiting

Study contacts

• Study coordinator: Shangrong Fan, M.D.
• Email: fanshangrong@163.com
• Phone: 86-755-83923333

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• GenSci142 as a vaginal treatment for bacterial vaginosis

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• Using a device to treat bacterial vaginosis and fungal infections in women

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• Examining the genital microbiome of male partners of women with recurrent bacterial vaginosis

  This study is testing if the bacteria in the genital area of men can affect how often their female partners get bacterial vaginosis and whether cleaning with a certain solution can help reduce this risk.

  Recruiting Hadassah Medical Organization · Jerusalem · NCT05963711

• Effects of a lactic acid gel on vaginal health

  This study is testing if the contraceptive Phexxi can improve vaginal health by increasing good bacteria and reducing discomfort for women.

  Recruiting Early Phase 1 Queen's Medical Center · Honolulu, Hawaii · NCT05753813

• Lactoferrin as an alternative to antibiotics for BV or yeast infections in women

  This study tests whether vaginal lactoferrin pessaries can replace oral antibiotics/antifungals for BV or candida infections in women.

  Recruiting Guy's and St Thomas' NHS Foundation Trust · London and 1 other locations · NCT05434104

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.