Using Probenecid to Reduce Frequent Urination in Certain Kidney Conditions

A Multi-center, Open-Label, Exploratory Study to Assess the Efficacy of PB in Decreasing the Urine Output and Increasing the Urine Osmolality in Patients With Hereditary Nephrogenic Diabetes Insipidus, Patients With Autosomal Dominant Polycystic Kidney Disease Treated With Tolvaptan, And Severely Polyuric Patients With Previous Lithium Administration (Serendipity-PB1)

This study is testing if Probenecid can help adults with certain kidney conditions, like ADPKD and NDI, reduce their frequent urination and improve their quality of life.

Quick facts

• Phase: Phase 2
• Study type: Interventional
• Enrollment: 36 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Mayo Clinic (Academic / other)
• Locations: 1 site (Jacksonville, Florida)
• Trial ID: NCT05190744 on ClinicalTrials.gov

What this trial studies

This clinical trial investigates the effectiveness and safety of Probenecid (PB) in reducing excessive urination associated with Autosomal Dominant Polycystic Kidney Disease (ADPKD) and various forms of Nephrogenic Diabetes Insipidus (NDI). Participants include adults diagnosed with these conditions who experience high urine output, particularly those previously treated with lithium. The study aims to determine if PB can help manage symptoms related to long-term treatment with Tolvaptan and improve overall patient quality of life. The trial is interventional and is currently in Phase 2.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with a diagnosis of ADPKD or NDI who produce more than 5000 ml of urine per day.

Not a fit: Patients with a glomerular filtration rate below 25 ml/min/1.73 m2 or those not meeting the specific inclusion criteria may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could significantly improve the quality of life for patients suffering from excessive urination due to these kidney conditions.

How similar studies have performed: While this approach is novel in the context of these specific conditions, similar studies have shown promise in managing symptoms of polyuria with other interventions.

Eligibility criteria

Inclusion Criteria:

* Male or female, ≥ 18 years of age (inclusive) at time of screening
* Diagnosis of one of the following:

  1. ADPKD(as delineated in cohort 1)
  2. Congenital NDI (as delineated in cohort 1)
  3. Lithium-induced NDI (as delineated in cohort 1)
* Glomerular filtration rate (GFR) ≥ 25 ml/min/1.73 m2 at time of screening visit calculated as in cohort
* 24 hours urine volume in baseline 1 visit ≥ 5000 ml/ day
* If hypertensive, blood pressure controlled on antihypertensives (\<130/80 mm Hg) at least 30 days before day 1. Antihypertensives may be adjusted at time of baseline 2 per PI discretion.
* Female participants (see details in cohort 1 inclusion criteria)
* Have read, understood, and provided written informed consent after the nature of the study has been fully explained and must be willing to comply with protocol requirements and study-related procedures.
* Negative urinary pregnancy test (if applicable) at baseline 2
* Capable of providing urine samples as dictated by the protocol

Exclusion Criteria:

* Advanced diabetes (e.g., glycosylated hemoglobin \[HgbA1c\] \>7.5%, and/or glycosuria by dipstick, significant proteinuria \[\>300 mcg albumin/mg creatinine\]), other significant kidney disease, kidney cancer, transplanted kidney, single kidney, kidney surgery within the past 6 months (including cyst drainage or fenestration) or acute kidney injury within 6 months prior to screening.
* Clinically significant incontinence, overactive bladder, or urinary retention (e.g., benign prostatic hyperplasia).
* Other significant chronic medical disease (heart failure, diabetes mellitus, liver disease, transient or persistent elevated transaminases)
* History of acute gout attack in the past 30 days
* History of clinically significant drug or alcohol abuse in the 2 years prior to screening visit.
* Uncontrolled hyperuricemia or active gout
* History of hepatotoxicity related to tolvaptan; or clinically significant liver disease or impairment; or alanine aminotransferase (ALT), aspartate aminotransferase (AST), or total bilirubin values \>1.2 x Upper Limit of Normal (ULN) during screening.
* Medical history or findings that preclude safe participation in the trial or participants who are likely to be non-compliant with trial procedures in the opinion of the investigator or medical monitor.
* Requirement for ongoing diuretic use.
* Participants who are currently taking, or are expected to be taking, strong or moderate CYP3A4 or CYP2C8 inhibitors or inducers including regular use of grapefruit juice, Seville oranges, or St. John's wort. If applicable, there should be a 14-day washout of these treatments prior to Day 1.
* Prior use of a sodium-glucose cotransporter 2 inhibitor (SGLT2i) (e.g., canagliflozin, dapagliflozin, empagliflozin, etc.) within the 2 months prior to screening visit or expected need for initiation of treatment with a SGLT2i inhibitor during the study. Current use of SGLT2i will be reviewed by PI and allow enrollment if patient has been on stable dose for at least 2 months.
* Prior use of a hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor within the 2 months prior to screening visit or expected need for initiation of treatment with a HIF-PH inhibitor during the study;
* Participants who have taken any investigational drug or used an investigational device within 30 days, or 5 half-lives, whichever is longer, prior to screening visit 1a or plan to participate in an interventional trial during the study.
* Allergy to probenecid
* History of persistent hyponatremia
* Positive test results for hepatitis B surface antigen (HBsAg).
* Positive test results for hepatitis C (HCV) antibody (Anti-HCV), with the exception of participants for whom the reflex HCV RNA titer test is negative.

Where this trial is running

Jacksonville, Florida

• Mayo Clinic — Jacksonville, Florida, United States (Recruiting)

Study contacts

• Principal investigator: Fouad Chebib, MD — Mayo Clinic
• Study coordinator: Trinity Hooks

Conditions Autosomal Dominant Polycystic Kidney Disease; Nephrogenic Diabetes Insipidus; Acquired Nephrogenic Diabetes Insipidus; Congenital Nephrogenic Diabetes Insipidus; Tolvaptan; ADPKD; Polycystic Kidney Disease; Nephrogenic diabetes insipidus