Using Pregabalin to Treat Postdural Puncture Headache
Pregabalin as Alternative to Epidural Blood Patch in Treatment of Postdural Puncture Headache: A Randomized Controlled Clinical Trial
This study is testing if Pregabalin can help adults aged 21 to 65 with postdural puncture headaches feel better compared to other common treatments.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Enrollment | 75 (estimated) |
| Ages | 21 Years to 65 Years |
| Sex | All |
| Sponsor | Al-Azhar University Academic / other |
| Locations | 1 site (Tanta) |
| Trial ID | NCT06271486 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effectiveness of Pregabalin, an anticonvulsant medication, in treating postdural puncture headache (PDPH) in adults aged 21 to 65. Participants will receive either Pregabalin, an epidural blood patch, or conservative treatment to assess pain relief and recovery outcomes. The study aims to determine if Pregabalin can provide significant relief from PDPH symptoms compared to standard treatments. The trial is designed to include a diverse group of participants while adhering to strict eligibility criteria.
Who should consider this trial
Good fit: Ideal candidates are adults aged 21 to 65 with a confirmed diagnosis of postdural puncture headache.
Not a fit: Patients with a history of convulsions, chronic headaches, or contraindications to regional anesthesia may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could offer a new effective option for patients suffering from postdural puncture headache.
How similar studies have performed: While the use of Pregabalin for various pain conditions has been explored, this specific application for postdural puncture headache is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * age from 21 to 65 years old, * both genders, * confirmed diagnosis of postdural puncture headache (PDPH) Exclusion Criteria: * patient refusal * known allergy to the drug used in the study * patients with a history of convulsions * chronic headaches * contraindications to regional anesthesia (such as local infection and coagulation abnormalities). * Clinical indications of elevated intracranial pressure or associated risk factors * Deteriorated patients
Where this trial is running
Tanta
- Neveen Kohaf — Tanta, Egypt (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.