Using pregabalin to manage pain after total knee replacement surgery
Effect of Perioperative Oral Pregabalin in Total Knee Replacement for Postoperative Pain
This study is testing if taking pregabalin before knee replacement surgery can help reduce pain and the need for opioids afterward.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | Bahrain Defence Force Hospital Academic / other |
| Locations | 1 site (Manama) |
| Trial ID | NCT06187922 on ClinicalTrials.gov |
What this trial studies
This interventional randomized control trial aims to evaluate the efficacy and safety of oral pregabalin in controlling postoperative pain in patients undergoing total knee replacement surgeries with regional anesthesia. A total of 120 patients will be randomly assigned to either a pregabalin group, receiving the medication preoperatively, or a control group, receiving no premedication. Both groups will receive standard multimodal analgesia during and after surgery, with their opioid consumption monitored to assess pain control effectiveness. The study seeks to determine if pregabalin can reduce the need for opioids post-surgery.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 85 who are undergoing elective total knee replacement under regional anesthesia.
Not a fit: Patients with chronic pain conditions, severe comorbidities, or those undergoing general anesthesia may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved pain management and reduced opioid consumption for patients after knee replacement surgery.
How similar studies have performed: Previous studies have shown that pregabalin can be effective in managing postoperative pain, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age between 18 to 85 year 2. Elective Regional anesthesia. 3. Able to follow study protocol Exclusion Criteria: 1. ASA -IV 2. Age \<18 \& \> 85 years 3. Patients on pregabalin for chronic neuropathic pain. 4. Patient under General anesthesia 5. Patients with chronic liver failure 6. Patients with chronic renal failure on Hemodialysis 7. Patients on opioid (\>3 month) 8. Patient with complicated knee surgery
Where this trial is running
Manama
- Bahrain Defence Force — Manama, Bahrain (Recruiting)
Study contacts
- Study coordinator: Mehtash Butt, Fcps,fcai
- Email: dr.mehtashbutt@yahoo.com
- Phone: +97336681277
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.