Using prebiotics to manage high uric acid levels
Precision Treatment of Hyperuricemia Based on Different Combinations of Prebiotics
NA · Sun Yat-sen University · NCT06420401
This study is testing if prebiotics can help people with high uric acid levels feel better and manage their condition by improving gut health.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 160 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Sun Yat-sen University (other) |
| Locations | 2 sites (Guangzhou, Guangdong and 1 other locations) |
| Trial ID | NCT06420401 on ClinicalTrials.gov |
What this trial studies
This trial investigates the effects of prebiotics on managing hyperuricemia, a condition linked to various chronic diseases. It aims to explore how prebiotics can influence gut microbiota and potentially delay the progression of hyperuricemia through mechanisms such as reducing endotoxemia and enhancing the production of beneficial metabolites. Participants will receive different forms of prebiotics or a placebo to assess their protective effects. The study will also examine whether individual gut microbiota profiles affect the outcomes of prebiotic treatment.
Who should consider this trial
Good fit: Ideal candidates are local residents aged 18-80 with stable weight and elevated fasting uric acid levels who are not currently on uric acid-lowering medications.
Not a fit: Patients with acute illnesses, chronic inflammatory diseases, or those on interfering diets or medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a novel dietary approach to managing hyperuricemia and reducing the risk of associated chronic diseases.
How similar studies have performed: Previous animal studies and pilot human trials have shown promising results with prebiotics in managing hyperuricemia, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Local residents aged between 18-80 years old; * Stable weight (\<5% weight change over the past 3 months); * Fsating uric acid \> 420 umol/L for male and \> 360 umol/L for female on two different days; * Not taking uric acid lowering drugs or have stopped taking uric acid lowering drugs for over 4 weeks at the time of recruitment; * Absence of any diet or medication that might interfere with uric acid metabolims or gut microbiota, especially antibiotics, prebiotics or probiotics at the least 4 weeks before recruitment Exclusion Criteria: * Acute illness or evidence of any acute or chronic inflammatroy of infective diseases; * Participation in regular diet program more than 2 times per week in the lastest 3 months prior to recruitment; * Mental illness rendering them unable to understand the nature, scope, and possible consequences of the study; * Women of childbearing age who are pregant, breast-feeding or preparing for pregnancy; patients who had surgey within the past 6 months or planned surgery during the trial period.
Where this trial is running
Guangzhou, Guangdong and 1 other locations
- Department of Nutrition and Food Hygiene — Guangzhou, Guangdong, China (RECRUITING)
- Sun Yat-Sen University — Guangzhou, Guangdong, China (RECRUITING)
Study contacts
- Study coordinator: Yan Liu, PhD
- Email: liuyan215@mail.sysu.edu.cn
- Phone: +86-20-87331974
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Subjects With Hyperuricemia