Using portal vein flow velocity to predict oesophageal varices in cirrhotic patients
Portal Vein Flow Velocity as a Screening Tool for Oesophageal Varices in Cirrhotic Patients
This study is testing if measuring blood flow in the portal vein can help doctors predict if people with cirrhosis have dangerous esophageal varices without needing expensive and invasive procedures.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 75 (estimated) |
| Sex | All |
| Sponsor | Assiut University Academic / other |
| Locations | 2 sites (Assiut, Manfalout and 1 other locations) |
| Trial ID | NCT05228509 on ClinicalTrials.gov |
What this trial studies
This study evaluates the use of portal vein flow velocity as a non-invasive screening tool to predict the presence of oesophageal varices in patients with cirrhosis, eliminating the need for costly and invasive upper endoscopy procedures. It aims to establish a correlation between portal vein flow velocity and the occurrence of oesophageal varices, assessing its efficacy as a primary diagnostic tool. The study will include both cirrhotic patients with and without varices to determine the predictive value of this measurement.
Who should consider this trial
Good fit: Ideal candidates for this study are cirrhotic patients, both those with and without oesophageal varices.
Not a fit: Patients with hepato-cellular carcinomas, portal vein thrombosis, hepatic encephalopathy, or those with positive HCV antibodies but without liver cirrhosis will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could provide a safer and more cost-effective method for screening cirrhotic patients for oesophageal varices.
How similar studies have performed: While the use of portal vein flow velocity as a screening tool is a novel approach, similar studies have explored non-invasive methods for predicting varices, but this specific methodology is less common.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * cirrhotic patients with oesophageal varices * cirrhotic patients without oesophageal varices Exclusion Criteria: * Patients with hepato-cellular carcinomas \[HCCs\], portal vein thrombosis, hepatic encephalopathy. * Patients with positive HCV antibody, but without liver cirrhosis diagnostic criteria
Where this trial is running
Assiut, Manfalout and 1 other locations
- 43 — Assiut, Manfalout, Egypt (Recruiting)
- Egypt .assiut.manfalout — Assiut, Manfalout, Egypt (Recruiting)
Study contacts
- Principal investigator: Peter At Munir, Master — Assiut University
- Study coordinator: Peter At Rizk
- Email: Peteratef662@gmail.com
- Phone: 01553529181
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.