Using portable air cleaners to improve heart failure outcomes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The ACHIEVE-P4: PATHFINDER project is a randomized, blinded clinical trial that provides portable air cleaners to heart failure patients at the time of hospital discharge. This study aims to assess whether reducing exposure to air pollution can improve clinical outcomes for these patients, particularly among those from disadvantaged backgrounds. Participants will be randomly assigned to receive either an active air cleaner or a sham device, and will also be provided with a PM2.5 sensor to monitor air quality in their homes. The trial is part of a broader initiative to address health disparities related to cardiometabolic conditions in urban populations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Currently in the emergency room or hospitalized with plan to be discharged to home, or
2. Diagnosis of heart failure
3. BNP\>200 ng/L or NTproBNP\>1000 ng/L during hospitalization or within 1 month prior to screening
4. Expected ability to fully participate in study (can tolerate study processes, no long travel)

Exclusion Criteria:

1. Hemodialysis dependent
2. If dialysis is being considered by participant's care team and their eGFR value is \<30 mL/min/1.73 sq m
3. Life expectancy of less than one year
4. Inability to provide written informed consent
5. Age less than 18 years old
6. Patients with a left ventricular assist device (LVAD)
7. Heart transplant recipients
8. Individuals who regularly use a HEPA air cleaner in their home at screening
9. Current smokers of nicotine or marijuana
10. Severe aortic or mitral valve disease
11. Has a scheduled, non-diagnostic cardiac procedure within 30 days prior, or in the next 90 days from screening (e.g. PCI, resynchronization, any cardiac surgery)
12. If the PI decides for any reason that participation in the trial is not in the best interest of the patient

Where it's running

• Henry Ford Health
  Detroit, Michigan, United States Recruiting

Study contacts

• Principal investigator: David Lanfear, MD — Henry Ford Health
• Study coordinator: Whitney Cabral, MS
• Email: WCABRAL1@hfhs.org
• Phone: 313-874-1887

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.