Using platelets rich plasma and PDO threads to treat stress incontinence in women
The Role of Platelets Rich Plasma Combined With PDO Threads in Treatment of Stress Incontinence in Egyptian Women
This study is testing if combining platelet-rich plasma with PDO threads can help women aged 20 to 45 who have severe stress urinary incontinence feel better after other treatments didn’t work.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 10 (estimated) |
| Ages | 20 Years to 45 Years |
| Sex | Female |
| Sponsor | Al-Azhar University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06885463 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the efficacy and safety of combining platelets rich plasma (PRP) with PDO threads for treating stress urinary incontinence (SUI) in women aged 20 to 45. It will involve 10 women who have severe urodynamic stress incontinence and have previously failed conservative treatments. The intervention will be conducted at the Department of Obstetrics and Gynecology at Al-Azhar University in Cairo, Egypt. Participants will be monitored for improvements in their symptoms and overall quality of life following the treatment.
Who should consider this trial
Good fit: Ideal candidates for this study are nonpregnant women aged 20 to 45 with severe stress urinary incontinence who have not responded to conservative treatments.
Not a fit: Patients with certain medical conditions such as active infections, malignancies, or those on anticoagulant therapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could provide a new, effective treatment option for women suffering from stress urinary incontinence.
How similar studies have performed: While this specific combination of treatments is novel, similar approaches using PRP for various conditions have shown promise in other studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Nonpregnant Women with SUI * Age between 20 to 45 years * Patients had a history of failed conservative treatment * Patients were on the waiting list for surgical treatment of SUI Exclusion Criteria: * Under anti-platelet agent treatment * Under NSAIDs * Platelet dysfunction syndrome * Critical thrombocytopenia * Hypofibrionogenaemia * Sepsis * Acute and chronic infections * Chronic liver disease * Anti-coagulation therapy * History of malignancy * Pregnancy * history of active malignant pathology * mental disorders making them unable to give consent * genitourinary fistula * pelvic organs prolapse stage \>2 according to the Pelvic Organ Prolapse Quantification system, and detrusor overactivity on urodynamics.
Where this trial is running
Cairo
- Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University. — Cairo, Egypt (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.