Using platelet-rich plasma to treat parosmia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of intranasal injections of platelet-rich plasma (PRP) in treating parosmia, a condition characterized by distorted smell. PRP, derived from the patient's own blood, is known for its anti-inflammatory and regenerative properties. The study will involve patients who have experienced olfactory distortion due to upper respiratory infections and will assess improvements in their olfactory function. Participants will also engage in concurrent olfactory training as part of the standard care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients \>= 18 years of age
* Patients who have qualitative olfactory distortion
* Etiology of qualitative olfactory distortion is due to upper respiratory infection
* Quantitative score under the 10th percentile on the SSParoT (HedRang and HedDir)
* Quantitative score ≥ 8 on the QOD.
* At least 6 months of parosmia but less than 24 months
* Patients can have been previously treated with oral and topical steroids but this is not a requirement
* Patients will receive concurrent olfactory training - the practice of smelling strong odors (standard of care)
* Be able to read and understand English
* Be able and willing to provide Informed Consent

Exclusion Criteria:

* Patients \< 18 years of age, pregnant females, patients who have structural abnormalities on nasal endoscopy or radiographic imaging that would prevent injection into the olfactory cleft
* Olfactory loss due to trauma, chronic sinusitis / inflammation / polyps, neoplasms, or neurodegenerative diseases or patients who have had olfactory loss \> 24 months
* Patients with bleeding disorders or on blood thinners such as coumadin and plavix

Where it's running

• Stanford Sinus Center / Stanford University School of Medicine
  Palo Alto, California, United States Recruiting

Study contacts

• Principal investigator: Zara Patel, MD — Stanford Otolaryngology - Head and Neck Surgery
• Study coordinator: Homer Abaya, BS
• Email: habaya@stanford.edu
• Phone: (650) 725-6500

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.