Home › Trials › NCT03808454
Clinical trial No longer in our active list Phase 4 Interventional Ages 18 to 70

Using Platelet Rich Plasma to Improve Recovery from Ankle Sprains

Official title: The Effect of Proprioception of Platelet Rich Plasma for Patients With Ankle Sprain

Run by National Defense Medical Center, Taiwan · NCT03808454 · Data updated 2026-05-14

This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.

This study is testing if Platelet Rich Plasma injections, alone or with rehab therapy, can help people recover faster and better from severe ankle sprains.

Quick facts

PhasePhase 4
Study typeInterventional
Ages18 Years to 70 Years
SexAll
Enrollment60 (estimated)
SponsorNational Defense Medical Center, Taiwan
Academic / other
Locations1 site (Taipei)
Trial IDNCT03808454 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are individuals with a recent ankle sprain (within one month) classified as second or third degree.

Probably not a fit

Patients with certain medical conditions such as cancer, liver cirrhosis, or those on anticoagulation therapy may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of Platelet Rich Plasma (PRP) injections combined with rehabilitation therapy for patients suffering from second and third-degree ankle sprains. Participants will be randomly assigned to one of three groups: general rehabilitation therapy, PRP injection therapy, or a combination of both. The study aims to evaluate the impact of these treatments on proprioception and overall clinical function using a new ankle proprioception evaluation system. The goal is to establish a more effective and rapid treatment method for ankle sprains, enhancing recovery and coordination.

Why it matters

Potential benefit: If successful, this treatment could significantly reduce recovery time and improve functional outcomes for patients with ankle sprains.

How similar studies have gone: Other studies have shown promising results with PRP therapy in similar contexts, suggesting potential for success in this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* ankle sprain within one months
* Gr II or Gr III ankle sprain (anterior talus fibular ligament)by sonogram proved
* MMSE≥23
* could cooperate the examination of the test

Exclusion Criteria:

* Hemianopsia or hemineglect any brain lesion such as cerebrum of cerebellum involved movement
* cancer victim
* pregnant If needed PRP treatment
* Liver cirrhosis
* Platelet \< 150000/UL
* Sepsis, Leukemia
* use anti-coagulation agents
* under hemodialysis

Where it's running

  • Tri-service General Hospital
    Taipei, Taiwan     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov ↗ Find more trials like this →
Browse more
National Defense Medical Center, Taiwan 12
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.