Using platelet-rich plasma to improve ovarian response in women with infertility

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of autologous platelet-rich plasma (PRP) intra-ovarian infusion in enhancing ovarian tissue functionality and improving outcomes in fresh embryo transfer-ICSI cycles for women diagnosed with Poor Ovarian Response (POR). The study employs a triple-blind randomized controlled trial design to assess the impact of PRP, which is enriched with growth factors, on patients' hormonal profiles and overall fertility. By comparing the effects of PRP against a placebo, the trial aims to provide insights into the potential benefits of this innovative treatment approach for women facing infertility challenges.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Poor Ovarian Response according to Bologna Criteria (fulfilling 2 out of 3 of the following)
* Age ≥ 40 years
* AMH \< 1.1 ng/ml OR AFC \< 7
* ≤ 3 oocytes with a conventional stimulation protocol)
* Discontinuation of any complementary/adjuvant treatment including hormone replacement, acupuncture, and botanotherapy, for at least three months prior to recruitment.
* Willing to comply with study requirements

Exclusion Criteria:

* Any pathological disorder related to reproductive system anatomy
* Cycle irregularities
* Amenorrhea
* Endometriosis
* Adenomyosis
* Fibroids and adhesions
* Infections in reproductive system
* Current or previous diagnosis of cancer in reproductive system
* History of familiar cancer in reproductive system
* Severe male factor infertility
* Prior referral for PGT
* Ovarian inaccessibility -Endocrinological disorders (Hypothalamus-
* Pituitary disorders, thyroid dysfunction, diabetes mellitus, metabolic syndrome)
* BMI\>30 kg/m2 or BMI\<18.5 kg/m2
* Systematic autoimmune disorders

Where it's running

• Genesis AC
  Athens, Greece Recruiting

Study contacts

• Study coordinator: Mara Simopoulou, PhD
• Email: marasimopoulou@hotmail.com
• Phone: +306979234100

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.