Using Platelet Rich Plasma to Improve Ovarian Function in Perimenopausal Women

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of autologous platelet rich plasma (PRP) intra ovarian infusion in enhancing ovarian tissue functionality and hormonal profiles in perimenopausal women. The study employs a triple-blind randomized controlled trial design, comparing the effects of PRP with a placebo treatment of autologous platelet free plasma (PFP). PRP, enriched with growth factors, is hypothesized to stimulate tissue proliferation and promote folliculogenesis. The trial aims to provide insights into the potential benefits of PRP for women experiencing infertility and menstrual cycle abnormalities during perimenopause.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women ≥40 years of age, presenting with cycle irregularities while fulfilling at least one of the respective two criteria: more than seven days difference in menstrual cycle duration between two consecutive cycles OR, presence of a menstrual cycle duration over sixty days and progressive elevation of FSH levels.
* Discontinuation of any complementary/adjuvant treatment including hormone replacement, acupuncture, and botanotherapy, for at least three months prior to recruitment.
* Willing to comply with study requirements

Exclusion Criteria:

* Any pathological disorder related to reproductive system anatomy
* Amenorrhea
* Endometriosis
* Adenomyosis
* Fibroids and adhesions
* Infections in reproductive system
* Current or previous diagnosis of cancer in reproductive system
* History of familiar cancer in reproductive system
* Severe male factor infertility
* Prior referral for PGT
* Ovarian inaccessibility
* Previous POI diagnosis -Endocrinological disorders (Hypothalamus-
* Pituitary disorders, thyroid dysfunction, diabetes mellitus, metabolic syndrome)
* BMI\>30 kg/m2 or BMI\<18.5 kg/m2
* Systematic autoimmune disorders

Where it's running

• Genesis AC
  Athens, Greece Recruiting

Study contacts

• Study coordinator: Mara Simopoulou, PhD
• Email: marasimopoulou@hotmail.com
• Phone: +306979234100

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.