Using Platelet Rich Plasma to Improve Endometrial Thickness in Infertile Women
Official title: Intrauterine Platelet Rich Plasma (PRP) Infusion for Endometrial Insufficiency: A Prospective, Double-Blind, Placebo-Controlled Randomized Controlled Trial
Run by Reproductive Medicine Associates of New Jersey · NCT05538338 · Data updated 2026-11-12
This study is testing if using Platelet Rich Plasma can help women with thin uterine lining improve their chances of getting pregnant through IVF.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 62 (estimated) |
| Sponsor | Reproductive Medicine Associates of New Jersey Academic / other |
| Locations | 1 site (Basking Ridge, New Jersey) |
| Status | Recruiting |
| Started | October 15, 2022 |
| Main results expected | October 2026 |
| Study ends | December 2027 |
| Registry record updated | June 3, 2026 |
| Trial ID | NCT05538338 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women with a history of at least two unsuccessful frozen embryo transfers and a diagnosed thin endometrial lining.
✕Probably not a fit
Patients who have not undergone at least two prior unsuccessful frozen embryo transfers or have certain uterine anomalies may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the effectiveness of intrauterine infusion of Platelet Rich Plasma (PRP) in increasing endometrial thickness and improving IVF outcomes in women with a history of thin endometrium. Participants will be randomly assigned to receive either PRP or a placebo saline infusion in a double-blind, placebo-controlled design. Following the infusion, patients will undergo a frozen embryo transfer of a single euploid embryo as per standard procedures. The goal is to determine if PRP can enhance the chances of achieving a successful pregnancy in this specific population.
Why it matters
Potential benefit: If successful, this approach could significantly improve pregnancy rates for women with thin endometrium who have struggled with infertility.
How similar studies have gone: While the use of PRP in reproductive medicine is gaining interest, this specific application for thin endometrium is relatively novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who have previously undergone at least 2 unsuccessful frozen embryo transfer cycles, defined as failure to achieve a sustained clinical pregnancy (visualization of intrauterine gestational sac on ultrasound or a cancelled embryo transfer cycle due to inadequate endometrial thickness * Patients with a diagnosis of thin endometrial lining (less than or equal to 6 mm maximum thickness) during prior unsuccessful or canceled embryo transfer cycles. Exclusion Criteria: * Fewer than 2 prior unsuccessful or canceled frozen embryo transfer cycles. * Most recent unsuccessful embryo transfer prior to January 1, 2017. * Mullerian anomalies, excluding arcuate uterus * Concurrent submucosal fibroids, unrepaired uterine defects or present indication for uterine surgery * Communicating hydrosalpinx without plans for surgical correction prior to study enrollment. * Failure of patient to agree to enrollment in study with written consent. * Concurrent pregnancy * Anticoagulation use for which plasma infusion is contraindicated * History of thrombosis * Thrombophilia either inherited or acquired * Concomitant use of adjunctive therapies for proliferation. These must be discontinued upon enrollment. * Embryo planned to be used for transfer generated from surgically obtained sperm due to a diagnosis of non-obstructive azoospermia * Recurrent/persistent endometrial fluid in prior cycles
Where it's running
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Reproductive Medicine Associates of New Jersey
Basking Ridge, New Jersey, United States Recruiting
Study contacts
- Study coordinator: Christine V Whitehead, BSN, RN
- Email: clinicalresearchteam@ivirma.com
- Phone: 19736562841
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Uterine transplant for women with infertility due to absence of uterus
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Uterus transplantation to help women with infertility
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.