Using platelet-rich fibrin to regenerate pulp in mature necrotic teeth
The Outcome of Pulp Revascularization of Necrotic Mature Permanent Teeth With Periapical Lesion Using Platelet-rich Fibrin Versus Induced Bleeding: Randomized Clinical Trial
This study is testing if using platelet-rich fibrin can help heal and regenerate the pulp in mature teeth that have died and have infection, compared to a standard method.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 12 Years to 60 Years |
| Sex | All |
| Sponsor | King Abdullah University Hospital Academic / other |
| Locations | 1 site (Irbid) |
| Trial ID | NCT06347640 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the effectiveness of platelet-rich fibrin (PRF) compared to induced bleeding in the pulp revascularization of mature necrotic teeth with periapical lesions. The study aims to address the limitations of conventional root canal treatments by potentially restoring the neurovascular system and immune response in these teeth. Fifty patients with necrotic mature teeth will be recruited to assess clinical and radiographic outcomes of the regenerative procedures. The trial focuses on a novel approach to enhance the chances of pulp tissue regeneration in fully formed teeth.
Who should consider this trial
Good fit: Ideal candidates include patients with anterior or posterior mature teeth diagnosed with necrotic pulp and a periapical lesion.
Not a fit: Patients with medically compromised conditions, previous root canal treatments, or non-restorable teeth will not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could provide a more effective alternative to traditional root canal therapy, potentially preserving the natural tooth structure and function.
How similar studies have performed: While some studies have explored the use of blood clot as a scaffold for regeneration, the use of platelet-rich fibrin in mature teeth is a relatively novel approach with limited prior research.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria 1. Anterior or posterior mature tooth diagnosed with necrotic pulp in the presence of a periapical lesion, 2. Pulp space is not needed for post and core restoration. 3. Patients are not allergic to the medicaments necessary to complete the procedure. Exclusion Criteria 1. Medically compromised patient. 2. Patient with generalized chronic periodontitis. 3. Teeth with previous root canal treatment. 4. Periodontal pocket larger than 3mm. 5. Teeth with vertical fractures 6. Non-restorable teeth
Where this trial is running
Irbid
- Jordan University of Science and Technology — Irbid, Jordan (Recruiting)
Study contacts
- Study coordinator: Lama Awawdeh, MSc, PhD
- Email: lawawdeh@just.edu.jo
- Phone: 0795412954
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.