Using Platelet Rich Fibrin to Help Bone Healing in Smokers
Platelet Rich Fibrin as a Modulator of the Wound Healing Response in Smokers
This study is testing if a special treatment called platelet-rich fibrin can help smokers heal better after tooth extractions and prepare for dental implants.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 16 (estimated) |
| Ages | 20 Years to 70 Years |
| Sex | All |
| Sponsor | Universidad de los Andes, Chile Academic / other |
| Locations | 2 sites (Santiago de Chile, Region Metropolitana and 1 other locations) |
| Trial ID | NCT06190860 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of leukocyte platelet-rich fibrin (L-PRF) on bone healing in smokers who require tooth extractions and subsequent implant rehabilitation. Participants will be randomly assigned to receive either L-PRF treatment or standard care after a thorough evaluation, including clinical examinations and radiographic assessments. The study aims to determine if L-PRF can enhance alveolar ridge preservation in smokers, a group known to experience impaired healing. The trial will be conducted at two dental institutions in Santiago, Chile, following ethical guidelines.
Who should consider this trial
Good fit: Ideal candidates are smokers who have been smoking at least five cigarettes a day for over a year and require tooth extractions with plans for implant rehabilitation.
Not a fit: Patients who are pregnant, taking immunosuppressive or anticoagulant medications, or have altered coagulation parameters may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could improve bone healing outcomes for smokers undergoing dental procedures.
How similar studies have performed: While L-PRF has shown promise in non-smokers, evidence regarding its efficacy in smokers is limited, making this approach relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Smokers (at least five cigarettes/day) have had the habit for at least one year. * treatment plan that includes the indication of extraction of a single, double-rooted, or multi-rooted tooth and prosthetic rehabilitation with osseointegrated implants * Patients with controlled systemic pathologies (hypertension, diabetes, hypercholesterolemia). * With alveolar bone support of at least 50% and whose indication is delayed implant placement at least four months after extraction. * Periapical lesions of no more than 5 mm diameter. Exclusion Criteria: * patients taking immunosuppressive or anticoagulant drugs * pregnant * users of removable prostheses * Individuals with altered values of platelet count or coagulation parameters.
Where this trial is running
Santiago de Chile, Region Metropolitana and 1 other locations
- Dental facility, Health center at San Bernardo, Faculty of Dentistry, University of the Andes — Santiago de Chile, Region Metropolitana, Chile (Recruiting)
- Clinical Facility, School of Dentistry, Pontificia Universidad Católica de Chile — Santiago de Chile, Región Metropolitana, Chile (Enrolling_by_invitation)
Study contacts
- Principal investigator: Constanza Martínez, DDS PhD — University of the Andes, Chile
- Study coordinator: Constanza Martínez, DDS PhD
- Email: cemartinezc@uandes.cl
- Phone: 56987660640
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.