Using platelet-lymphocyte and platelet-neutrophil ratios to detect early trauma-related coagulopathy
Predictive Accuracy of Platelet Lymphocyte Ratio & Platelet Neutrophil Ratio in Detecting Early Trauma Induced Coagulopathy
This research will test if blood-count ratios (PLR and PNR) taken within six hours of injury can help detect early trauma-induced coagulopathy in patients who come to the emergency department.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 250 (estimated) |
| Ages | 12 Years and up |
| Sex | All |
| Sponsor | Jubilee Mission Medical College and Research Institute Academic / other |
| Locations | 1 site (Thrissur, Kerala) |
| Trial ID | NCT07046858 on ClinicalTrials.gov |
What this trial studies
Patients presenting to the emergency department within six hours of mechanical trauma will have on-admission complete blood counts used to calculate platelet-lymphocyte ratio (PLR) and platelet-neutrophil ratio (PNR). This observational study compares those ratios to standard coagulation profiles obtained during the hospital stay to determine how accurately PLR and PNR identify early trauma-induced coagulopathy (ETIC). Individuals treated elsewhere before arrival, with non-mechanical injuries, or with chronic conditions or medications that affect coagulation are excluded to reduce confounding. The aim is to validate simple, low-cost biomarkers that could support early risk stratification and timely referral in resource-limited hospitals.
Who should consider this trial
Good fit: Patients with mechanical trauma who present to the emergency department within six hours of the event and for whom the ED physician orders a coagulation profile are eligible.
Not a fit: Patients who received intravenous fluids, drugs, whole blood or blood products elsewhere, those with non-mechanical injuries (drowning, hanging, burns), or those with chronic liver or renal disease, malignancy, hematologic disorders, or on medications affecting coagulation are unlikely to benefit from these specific biomarkers.
Why it matters
Potential benefit: If successful, simple on-admission PLR and PNR measurements could enable earlier identification and referral of trauma patients at risk of coagulopathy, improving timely management especially in resource-limited settings.
How similar studies have performed: Some prior small studies have linked PLR and PNR to outcomes in stroke, cardiovascular disease, abdominal trauma, ARDS, and sepsis, but using these ratios specifically to detect early trauma-induced coagulopathy is relatively novel and not yet well established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients with trauma AND * Presenting to ED within 6 hours of the event AND * The ED Physician sends coagulation profile Exclusion Criteria: * Treated with intravenous fluids, drugs, whole blood and blood products elsewhere * Patients admitted with a non-mechanical mechanism of injury, specifically drowning, hanging,or burns, as these mechanisms may result in a different biologic response than mechanical trauma * Patients on known medications affecting coagulation profile or hemogram * Patients with known chronic liver disease, chronic renal failure, malignancy, hematological disorders * Patients not consenting for the study
Where this trial is running
Thrissur, Kerala
- Jubilee Mission Medical College — Thrissur, Kerala, India (Recruiting)
Study contacts
- Study coordinator: Dr Siju V Abraham, MBBS MD
- Email: sijuvabraham@gmail.com
- Phone: +919447754321
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.