Using placental growth factor (PlGF) to signal fetal brain injury after prenatal alcohol exposure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will collect a blood sample from pregnant women with and without alcohol exposure and measure placental growth factor (PlGF). Children will be followed and evaluated with standardized development and behavior scales, including ASQ, Conners, SCQ, and formal developmental testing at about 2 and 6 years of age. Alcohol exposure is defined as chronic consumption of ≥30 g/week or binge episodes, with a no-alcohol control group for comparison. The aim is to validate whether maternal PlGF correlates with later cerebral lesions and developmental outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Mother:

* Pregnant woman (monofetal or twin pregnancy, whatever the parity)
* Age\> or = to 18 years
* Person affiliated to a social security system
* Person who read and understood the information form and signed the consent form

  * Alcohol exposure group Chronic consumption of at least 30 g of alcohol per week or acute consumption of "binge drinking" type during pregnancy (knowing that a unit of 10 g of pure alcohol corresponds to 25 cl of beer 4 ° 5, 10 cl of wine at 12 °, 3 cl of whiskey, 7 cl of Porto ...)
  * Control group No alcohol consumption during pregnancy
  * Child Informed parents and written consent signed by the father and mother for the child's participation in this research (unless one of the parents does not have parental authority)

Exclusion Criteria:

* Female under 18
* Pregnant woman with clinical suspicion of pre-eclampsia and / or HELLP syndrome
* Person deprived of liberty by an administrative or judicial decision or protected major subject (under tutorship or curatorship)
* Patient participating in another interventional trial or who participated in another interventional trial during pregnancy

Where it's running

• Uh Rouen
  Rouen, France Recruiting

Study contacts

• Study coordinator: Pourcher
• Email: cecile.pourcher@chu-rouen.fr
• Phone: 02 32 88 82 65

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.