Using pink noise to improve memory in Alzheimer's patients
Effects of Auditory Brain Stimulation by "Pink Noise" on Memory Capacities in Alzheimer's Disease: Proof of Concept Study
This study tests if listening to pink noise can help improve memory in people with early-stage Alzheimer's disease.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 50 Years and up |
| Sex | All |
| Sponsor | University Hospital, Tours Academic / other |
| Locations | 1 site (Tours) |
| Trial ID | NCT04570761 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of auditory brain stimulation using pink noise on memory consolidation in individuals with Alzheimer's disease (AD). The approach is based on the premise that sleep enhances memory consolidation, and pink noise may facilitate this process. Participants will include both individuals diagnosed with early-stage Alzheimer's and healthy volunteers matched by age and sex. The study aims to determine whether this novel stimulation method can strengthen memory capacities in patients with neurodegenerative conditions.
Who should consider this trial
Good fit: Ideal candidates include individuals over 50 years old with early-stage Alzheimer's disease and regular sleep patterns.
Not a fit: Patients with advanced Alzheimer's disease or significant psychiatric disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could provide a new therapeutic option to enhance memory function in Alzheimer's patients.
How similar studies have performed: While studies have shown pink noise to be effective in healthy individuals, this application in Alzheimer's patients is novel and untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria common to all participants: * Age\> 50 years at the inclusion * Patient with regular sleep patterns * Patient having given written consent * Patient affiliated to a social security regimen Inclusion criteria for subjects with Alzheimer's disease: * Patient with a beginning Alzheimer's disease defined according to the criteria of the National Institute on Aging-Alzheimer's Association or carriers of a prodromal Alzheimer's disease defined according to the criteria of the International Working Group IWG-2; the diagnosis must be supported by brain imaging and a blood test carried out in routine care * MMSE score ≥ 24 Inclusion criteria for healthy volunteers: * Absence of neurodegenerative pathologies * Matched in age (+/- 5 years) and in sex with a patient Non-inclusion criteria common to all participants: * Psychiatric pathologies (except depression or anxiety disorders stabilized for more than 3 months) * History of pathology which may have consequences on cognitive functioning and / or sleep: brain tumor, constituted stroke, epilepsy, head trauma (with clinical or parenchymal sequelae objectified on brain imagery), brain surgery * Any significant comorbidity likely to constitute a confounding factor according to the clinician * Psychotropic treatments introduced or modified \<3 months before inclusion * Hypnotic and / or sedative treatments * Chronic consumption of alcohol or drugs * Legal incapacity and / or other circumstance rendering the patient unable to understand the nature, objective or consequences of the study * Major under guardianship or curatorship * Patient not French-speaking by birth or illiterate Exclusion Criteria common to all participants: * Sleep disorders defined by a score\> 5 on the Pittsburg sleep quality index (PSQI) * A score\> 10 on the Epworth sleepiness index
Where this trial is running
Tours
- University Hospital of Tours — Tours, France (Recruiting)
Study contacts
- Study coordinator: Anna-Chloé BALAGEAS, PhD
- Email: a.balageas@chu-tours.fr
- Phone: 0234378952
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.