Using PET/MRI to improve detection of lymph node metastases in cervical cancer
Official title: Contribution of PET/MRI in Locally Advanced Cervical Cancer
Run by Centre Paul Strauss · NCT06083103 · Data updated 2026-11-12
This study is testing if a new imaging method called PET/MRI can better find lymph node cancer spread in patients with advanced cervical cancer compared to the standard PET/CT scan.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 50 (estimated) |
| Sponsor | Centre Paul Strauss Academic / other |
| Locations | 1 site (Strasbourg) |
| Status | Recruiting |
| Started | October 12, 2023 |
| Main results expected | September 11, 2026 |
| Study ends | September 11, 2026 |
| Registry record updated | February 2, 2026 |
| Trial ID | NCT06083103 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged 18 and older with presumed cervical cancer stages IB2 to IVA who are undergoing pre-treatment assessment.
✕Probably not a fit
Patients with a history of other cancers that could affect imaging results or those with contraindications to MRI will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational trial aims to evaluate the effectiveness of 18F-FDG positron emission tomography-magnetic resonance imaging (PET/MRI) compared to standard PET/CT in detecting lymph node metastases in patients with locally advanced cervical cancer. The study will involve patients aged 18 and older who are undergoing pre-treatment assessment for cervical cancer stages IB2 to IVA. Both imaging techniques will be performed sequentially using the same dose of radiotracer to ensure consistency in results.
Why it matters
Potential benefit: If successful, this study could enhance the accuracy of lymph node metastasis detection in cervical cancer, leading to better treatment planning.
How similar studies have gone: Previous studies have shown that PET/MRI may have better sensitivity than PET/CT in detecting metastatic lymph nodes, suggesting potential for success in this novel application.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged from 18 years old and over * Patients with presumed cervical cancer of stages IB2 to IVA based on clinical data and pelvic MRI, undergoing pre-treatment assessment. * For women of childbearing potential : Adequate contraception throughout study participation. Note : enrollment in a concomitant clinical trial is authorized Exclusion Criteria: * Oncological history that could possibly interfere with imaging results interpretation, apart from cervical cancer * Extra-nodal metastasis clinically or radiologically proven before study participation * Contraindication to MRI or injection of contrast agents containing gadolinium * Contraindication to lumbo-aortic lymphadenectomy * Persons deprived of liberty * Minor or patients placed under guardianship or supervision * Patient under judicial protection * Patient unable to consent
Where it's running
-
Institut de cancérologie Strasbourg Europe
Strasbourg, France Recruiting
Study contacts
- Study coordinator: Claire VIT
- Email: promotion-rc@icans.eu
- Phone: (0)3 88 25 85 29
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.