Using personalized walking models to enhance surgery and rehabilitation for pelvic sarcoma patients
CPRIT: Optimizing Surgical and Rehabilitation Treatment of Pelvic Sarcomas Using Computational Models
This study is testing if personalized walking models can help improve surgery and recovery for patients with pelvic sarcomas by tailoring treatment to their specific needs.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 130 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | M.D. Anderson Cancer Center Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Houston, Texas) |
| Trial ID | NCT05054335 on ClinicalTrials.gov |
What this trial studies
This trial focuses on developing individualized computational walking models to improve surgical planning and rehabilitation for patients with pelvic sarcomas. By analyzing each patient's unique pelvic anatomy and tumor characteristics, the study aims to predict the best surgical methods and rehabilitation strategies to optimize post-surgery walking function. Patients will undergo assessments using advanced imaging techniques and motion capture both before and after hemipelvectomy procedures. The goal is to enhance functional outcomes through tailored surgical and rehabilitation decisions.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who are scheduled to receive an internal hemipelvectomy at UT MD Anderson Cancer Center.
Not a fit: Patients who have undergone certain types of previous surgeries or have specific medical conditions that affect hip movement may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve walking function and quality of life for patients recovering from pelvic sarcoma surgeries.
How similar studies have performed: While the use of computational models in surgical planning is an emerging field, similar approaches have shown promise in other areas of orthopedic surgery.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients who have received or are scheduled to receive an internal hemipelvectomy with or without reconstruction at UT MD Anderson Cancer Center. 2. Patients who are 18 years of age and older Exclusion Criteria: 1. Patients who have undergone an external (hindquarter amputated), or an isolated type III internal hemipelvectomy. 2. Previous surgery or significant injury to either hip (prospective patients only) 3. Relevant surgery, procedure, injury, or condition in the last two years which may affect hip pain or general movement patterns on either side (prospective patients only) 4. Pregnant women or women nursing an infant 5. Persons with a pacemaker, hearing aid, aneurysm clips or artificial heart valves, and other forms of loose metal implants will be excluded from the study as assessed by a pre-MRI questionnaire administered by the MRI technician at the time of the scan. 6. Radiological exclusion criteria (assessed after MR scan is conducted on the first visit, prior to DSX/CT radiation exposure): evidence on preliminary MRI of fracture, slipped capital femoral epiphysis (SCFE), masses, lesions, or other anomalies not consistent with an FAI diagnosis.
Where this trial is running
Houston, Texas
- M D Anderson Cancer Center — Houston, Texas, United States (Recruiting)
Study contacts
- Principal investigator: Valerae O Lewis — M.D. Anderson Cancer Center
- Study coordinator: Valerae O Lewis, BS,MD
- Email: volewis@mdanderson.org
- Phone: (713) 792-5073
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.