Using Perfusion Index to Guide Vasopressor Treatment in Sepsis
Can Perfusion Index Indicate the Need of Vasopressor in ICU Patients with Sepsis and Septic Shock, Prospective Observational Study
This study is testing if using the perfusion index can help doctors decide when to start a specific medication for ICU patients with sepsis to improve their recovery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06860438 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the effectiveness of the perfusion index (PI) as a noninvasive indicator of peripheral microcirculation in ICU patients experiencing sepsis and septic shock. By monitoring PI, the study seeks to determine the optimal timing for initiating vasopressor treatment, specifically norepinephrine, to improve patient outcomes. The research will involve ICU patients who exhibit signs of sepsis and septic shock, with a focus on understanding the relationship between PI and hemodynamic stability. The findings could provide insights into personalized treatment strategies for managing sepsis.
Who should consider this trial
Good fit: Ideal candidates for this study are ICU patients with clinically suspected sepsis and septic shock.
Not a fit: Patients who are pregnant, currently on vasopressors, or have certain circulatory impairments will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved management of sepsis, potentially reducing mortality rates associated with septic shock.
How similar studies have performed: While the use of perfusion index in sepsis management is a growing area of interest, this specific approach remains novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: \- All ICU patients with clinically suspected sepsis and septic shock ( signs include fever hypotension oliguria and confusion combined with culture results showing infection .Septic shock is a subset of sepsis involves persistent hypotension (mean arterial pressure ≥ 65 mm Hg, and a serum lactate level \> 18 mg/dL \[2 mmol/L)not responding to fluid resuscitation ) . Exclusion Criteria: * Pregnant females * Patients on vasopressor or positive inotropic drugs * Patients with hypothermia (defined as central temperature \<35°C). * Patient with impairment of upper extremity circulation,(such as those who underwent radial artery harvesting for coronary artery bypass grafting or had suspected occlusion of the radial artery prior to surgery,) * Patients had undergone an operation that involved the large arteries of the aortic arch. * Patients with atherosclerosis .
Where this trial is running
Cairo
- faculty of medicine Ain Shams University — Cairo, Egypt (Recruiting)
Study contacts
- Principal investigator: Nancy shaker ass,lecurer — faculty of medicine, Ain Shams University
- Study coordinator: Nancy Shaker ass.lecturer
- Email: nancy.shaker@med.asu.edu.eg
- Phone: 00201067003436
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.