Using Perfusion Index to Guide Vasopressor Treatment in Sepsis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the effectiveness of the perfusion index (PI) as a noninvasive indicator of peripheral microcirculation in ICU patients experiencing sepsis and septic shock. By monitoring PI, the study seeks to determine the optimal timing for initiating vasopressor treatment, specifically norepinephrine, to improve patient outcomes. The research will involve ICU patients who exhibit signs of sepsis and septic shock, with a focus on understanding the relationship between PI and hemodynamic stability. The findings could provide insights into personalized treatment strategies for managing sepsis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

\- All ICU patients with clinically suspected sepsis and septic shock ( signs include fever hypotension oliguria and confusion combined with culture results showing infection .Septic shock is a subset of sepsis involves persistent hypotension (mean arterial pressure ≥ 65 mm Hg, and a serum lactate level \> 18 mg/dL \[2 mmol/L)not responding to fluid resuscitation ) .

Exclusion Criteria:

* Pregnant females
* Patients on vasopressor or positive inotropic drugs
* Patients with hypothermia (defined as central temperature \<35°C).
* Patient with impairment of upper extremity circulation,(such as those who underwent radial artery harvesting for coronary artery bypass grafting or had suspected occlusion of the radial artery prior to surgery,)
* Patients had undergone an operation that involved the large arteries of the aortic arch.
* Patients with atherosclerosis .

Where it's running

• faculty of medicine Ain Shams University
  Cairo, Egypt Recruiting

Study contacts

• Principal investigator: Nancy shaker ass,lecurer — faculty of medicine, Ain Shams University
• Study coordinator: Nancy Shaker ass.lecturer
• Email: nancy.shaker@med.asu.edu.eg
• Phone: 00201067003436

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.