Using Pentoxifylline to Improve Sperm Selection in Infertile Men
The Efficacy of Pentoxifylline on Sperm Selecting in Intracytoplasmic Sperm Injection (ICSI) of Absolute Asthenozoospermia
This study is testing if a medication called Pentoxifylline can help improve sperm selection for men with very low sperm movement to increase their chances of successful fertilization during a specific fertility treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 10 (estimated) |
| Sex | Male |
| Sponsor | Mỹ Đức Hospital Academic / other |
| Locations | 1 site (Ho Chi Minh City) |
| Trial ID | NCT05943353 on ClinicalTrials.gov |
What this trial studies
This study investigates the use of Pentoxifylline, a drug that enhances sperm motility, to improve the selection of viable sperm for intracytoplasmic sperm injection (ICSI) in men with absolute asthenozoospermia, a condition characterized by complete immobility of sperm. The research aims to evaluate the effectiveness of Pentoxifylline in increasing fertilization rates by allowing embryologists to identify live but immotile sperm. The study will involve patients who have undergone sperm collection through procedures like PESA or TESE, where sperm motility is severely compromised. By assessing the outcomes of ICSI with Pentoxifylline, the study seeks to optimize treatment protocols for male infertility.
Who should consider this trial
Good fit: Ideal candidates for this study are men diagnosed with absolute asthenozoospermia who have completely immotile sperm after ejaculation or surgical sperm collection.
Not a fit: Patients who have viable motile sperm or those undergoing oocyte maturation cycles in vitro may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly enhance fertility treatment outcomes for men with severe sperm motility issues.
How similar studies have performed: While the application of Pentoxifylline in ICSI has not been previously tested in Vietnam, other studies have shown promising results in enhancing sperm motility and selection in similar contexts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Sperm are completely immotile since PESA, TESE and MicroTESE * Sperm are completely immotile after ejaculation Exclusion Criteria: * Oocyte maturation cycle in vitro
Where this trial is running
Ho Chi Minh City
- IVFMD, My Duc Hospital — Ho Chi Minh City, Vietnam (Recruiting)
Study contacts
- Principal investigator: Tuong M Ho, M.D — Mỹ Đức Hospital
- Study coordinator: Tuong M Ho, M.D
- Email: tuongho.ivfmd@gmail.com
- Phone: +84903633377
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.