Using PEEP and EIT to keep lungs open in babies born before 32 weeks

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Preterm infants under 32 weeks who are receiving CPAP or mechanical ventilation are enrolled within their first two weeks of life. Investigators use electrical impedance tomography (EIT) to guide and compare different levels of positive end expiratory pressure (PEEP)/continuous distending pressure to find settings that best recruit the lungs without causing harm. Outcomes include measures of lung recruitment, need for or duration of mechanical ventilation, and safety events such as pneumothorax or skin issues. The intervention is performed at a single center with parental informed consent and excludes infants with major congenital anomalies, pneumothorax, high-frequency ventilation, or skin integrity concerns.

Why it matters

Who can join: the full rules

Inclusion criteria

1. Gestational age \<32 weeks based on mother's last menstrual period or first trimester ultrasound dating.
2. Receiving either CPAP or mechanical ventilation respiratory support.
3. Informed written consent from one of the parents.
4. Within the first two weeks of life. Investigators pragmatically chose this period, as there could be considerable lung injury after the first two weeks of life, making it difficult to test our hypothesis. Also, this time period would allow parents to settle down with their stressful preterm delivery and investigators could approach anytime within the first two weeks of life.

Exclusion criteria

1. Major congenital malformations including congenital lung disease and congenital heart disease as ascertained by the medical team.
2. Infants diagnosed with pneumothorax i.
3. Receiving high frequency mechanical ventilation.
4. Infants with concerns of skin integrity.

Where it's running

• South Tees NHS Trust
  Middlesbrough, United Kingdom Recruiting

Study contacts

• Study coordinator: Prakash Kannan Loganathan, MD
• Email: pkannanloganathan@nhs.net
• Phone: +447481492632

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Risks of lung-opening maneuvers and PEEP adjustments in ventilated children

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• Using EIT to personalize PEEP during bariatric surgery

  This will test whether using electrical impedance tomography (EIT) to set personalized PEEP during laparoscopic bariatric surgery reduces postoperative lung complications compared with a fixed PEEP of 8 cmH2O in adults with obesity.

  Recruiting Qianfoshan Hospital · Jinan, Shandong · NCT07207772

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.