Using patients' own skin cells to heal large deep wounds
Amplification of Autologous Epidermal Cells to Repair Large Area Deep Wounds
This study is testing whether using a patient's own skin cells can help heal large deep burns more effectively than traditional skin grafts.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Sex | All |
| Sponsor | First Affiliated Hospital of the Chinese People's Liberation Army Naval Medical University Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Trial ID | NCT05882110 on ClinicalTrials.gov |
What this trial studies
This study focuses on the transplantation of autologous epidermal cells to treat large deep burns. It involves taking small pieces of a patient's skin, culturing and amplifying these cells in a lab, and then transplanting them back to the wound site to promote healing. The approach aims to overcome the limitations of traditional skin grafting methods, which often require multiple procedures and can lead to complications such as scarring. By significantly expanding the available skin cells, the study seeks to provide a more effective solution for patients with extensive skin damage.
Who should consider this trial
Good fit: Ideal candidates for this study are patients with at least 30% total body surface area trauma requiring prolonged healing.
Not a fit: Patients with less than 30% body surface area trauma will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could greatly enhance wound healing and improve the quality of life for patients with severe burns.
How similar studies have performed: While similar approaches in skin tissue engineering have shown promise, this specific method of amplifying epidermal cells for large deep wounds is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with a body surface trauma of 30% TBSA or more and a wound that requires at least 2 weeks to repair as assessed by the clinician Exclusion Criteria: * Patient body surface trauma area less than 30% TBSA
Where this trial is running
Shanghai, Shanghai Municipality
- Yicheng Ma — Shanghai, Shanghai Municipality, China (Recruiting)
Study contacts
- Study coordinator: Yicheng Ma
- Email: 15185903573@163.com
- Phone: 15185903573
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.