Using patients' own immune cells to improve endometrial health for infertility treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of intrauterine administration of autologous peripheral blood mononuclear cells (PBMC) on the populations of endometrial cells in women experiencing infertility. The research aims to understand how these immune cells can alter the endometrial environment, potentially enhancing embryo implantation success during assisted reproduction treatments. By focusing on the immune profile of the endometrium, the study seeks to provide insights into improving IVF outcomes through cellular composition changes. Participants will receive PBMC treatment to evaluate its impact on their endometrial health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participating in Assisted Reproduction Treatment
* Presenting altered endometrial immune profile
* Having primary infertility
* Having regular menstrual cycles
* Embryo transfer of euploid embryos

Exclusion Criteria:

* Uterine pathologies
* Endometrial Bacterial infections
* Active endometrial inflammation
* Polycystic ovary syndrome
* Presence of auto anti-bodies such as anti-TPO, anti-TG, ACA, APA, ANA, and anti-dsDNA
* Presence of mutations involving the coagulation system such as deficiency of factor XII, Pro C, Pro S
* Cancer diagnostics
* Positive HIV, HCV or HBV tests

Where it's running

• Nadezhda Women's Health Hospital
  Sofia, Sofia, Bulgaria Recruiting
• Medical diagnostic laboratory Imunovita
  Sofia, Bulgaria Recruiting

Study contacts

• Study coordinator: Georgi Stamenov, MD
• Email: g.stamenov@abv.bg
• Phone: +359888269839

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.