Using patient's own blood to treat gum recession
Volumetric Changes of Soft Tissue Grafting. Comparison of Autologous PRF (Platelet-rich Fibrin ) & Autogenous CTG (Connective Tissue Grafts) . A Split-mouth Randomized Design
This study is testing whether using a patient's own blood or tissue can help treat gum recession for those looking to improve their smile or reduce sensitivity.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Tufts University Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Trial ID | NCT05633511 on ClinicalTrials.gov |
What this trial studies
This study aims to address gum recession by utilizing a patient's own tissue from the roof of the mouth or an alternative method using their blood to create a membrane for treatment. Patients seeking corrective surgery for aesthetic concerns or sensitivity will be enrolled and randomly assigned to different treatment sites. An intraoral scanner will be used to measure pre-operative volume and will be repeated at each follow-up visit over the anticipated five-year duration of the study. The study employs a split-mouth design to compare the effectiveness of the two approaches.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who require treatment for gum recession at two or more sites.
Not a fit: Patients who smoke, do not consent to the therapy, or cannot comply with follow-up protocols may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could provide a less invasive and more acceptable treatment option for patients with gum recession.
How similar studies have performed: While the use of blood-derived membranes is a promising approach, the specific methodology in this study is relatively novel and has not been extensively tested in similar studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Adults 18yrs or older 2. Need of MG-tx for 2 or more sites for root coverage RT I and II (Cairo classification) 3. Class A +/- 4. No class V restoration present Exclusion Criteria: 1. Patients who do not consent to recommended therapy 2. Patients who smoke 3. Patients who will not be able to comply with follow up protocols 4. Those who self report that they are pregnant.
Where this trial is running
Boston, Massachusetts
- Tufts University School of Dental Medicine — Boston, Massachusetts, United States (Recruiting)
Study contacts
- Principal investigator: Tannaz Shapurian, DMD, MSc — Tufts University School of Dental Medicine
- Study coordinator: Tannaz Shapurian, DDM, MSc
- Email: Tannaz.shapurian@tufts.edu
- Phone: 617.636. 6741
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.