Using patients' own blood to reduce transfusion needs after heart surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial evaluates the feasibility of implementing a routine practice of retrograde autologous priming (RAP) compared to traditional crystalloid priming during cardiac surgeries. By using patients' own blood to prime the heart-lung machine, the study aims to minimize red blood cell (RBC) loss and reduce the need for transfusions. Conducted across four hospitals, the trial will alternate between the two priming methods over 12 periods, involving approximately 4500 cardiac surgery patients. The results will inform whether a larger trial is warranted to confirm the benefits of RAP in reducing transfusion requirements.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Hospitals completing \>200 adult cardiac surgical cases a year; (ii) 95% of cardiovascular surgery group (i.e., cardiac anesthesiologists, surgeons, and perfusionists) agree to manage patients under both autologous priming policies as per their randomization schedule for the duration of the trial.
* All patients undergoing cardiac surgery on cardiopulmonary bypass at an enrolled site during the trial period will be included in data collection.

Exclusion Criteria:

* Complete \<=200 cardiac surgical cases.
* \<95% of their cardiovascular surgery group agrees to manage patients according to either of the two policies.

Where it's running

• St. Boniface Hospital
  Winnipeg, Manitoba, Canada Recruiting
• Hamilton General Hospital
  Hamilton, Ontario, Canada Recruiting
• Montreal Heart Institute
  Montreal, Quebec, Canada Recruiting
• Centre Hospitalier de l'Université de Montréal (CHUM)
  Montreal, Quebec, Canada Recruiting

Study contacts

• Principal investigator: Jessica Spence, MD, PhD — Population Health Research Institute
• Study coordinator: TheRAPy Study Coordinator
• Email: therapy@phri.ca
• Phone: 9055212100

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.