Using Pantoprazole to Prevent Nausea After Gynecologic Surgery
Official title: Preoperative Use of Pantoprazole for Prevention of Post Operative Nausea and Vomiting in Gynecologic Surgery
Run by United States Naval Medical Center, Portsmouth · NCT06488001 · Data updated 2026-11-12
This study is testing if giving pantoprazole can help women avoid nausea and vomiting after gynecologic surgery.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 79 Years |
| Sex | Women only |
| Enrollment | 132 (estimated) |
| Sponsor | United States Naval Medical Center, Portsmouth Federal |
| Locations | 1 site (Portsmouth, Virginia) |
| Status | Recruiting |
| Started | August 26, 2022 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | May 21, 2025 |
| Trial ID | NCT06488001 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged 18 to 79 undergoing elective gynecologic surgery under general anesthesia.
✕Probably not a fit
Patients who are pregnant, have gastrointestinal diseases requiring ongoing management, or have a history of severe PONV may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate the effectiveness of pantoprazole, a proton pump inhibitor, in reducing postoperative nausea and vomiting (PONV) in women undergoing elective gynecologic surgery. Participants will be randomly assigned to receive either pantoprazole or a placebo, with medication administered before and after surgery. The study will utilize a double-blind design to ensure unbiased results, and postoperative nausea will be assessed using a visual analog scale. The trial is part of an enhanced recovery after surgery (ERAS) protocol that includes standard anti-nausea medications.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of postoperative nausea and vomiting, improving recovery experiences for patients.
How similar studies have gone: Previous studies have shown varying degrees of success with similar approaches, but this specific use of pantoprazole for PONV prevention is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Undergoing elective gynecological surgery by either an open abdominal or minimally invasive approach (to include both endoscopic and vaginal). Procedure must be performed under general anesthesia. Exclusion Criteria: * Pregnant, * Patients with gastrointestinal disease requiring ongoing medical management. * Prior gastrointestinal surgery with the exception of diagnostic procedures, appendectomy and cholecystectomy. * Patients with a history of H2 receptor blocker use, proton pump inhibitor use or other GERD specific therapy within 30 days of surgery. * Any patient identified by their surgical care team as having a history of PONV warranting additional perioperative prophylaxis. * Known r suspected malignancy * Lactose intolerance
Where it's running
-
Naval Medical Center Portsmouth
Portsmouth, Virginia, United States Recruiting
Study contacts
- Principal investigator: Casey Timmerman, DO — United States Naval Medical Center, Portsmouth
- Study coordinator: Casey Timmerman, DO
- Email: casey.j.timmerman2.mil@health.mil
- Phone: 757-953-7767
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.