Using ozone therapy to reduce complications after wisdom tooth surgery
Application of Gaseous Ozone in the Surgical Extraction of Impacted Mandibular Third Molars: Impact on the Incidence of Postoperative Complications and Healing Processes
This study is testing whether ozone therapy can help people recover better and have fewer problems after getting their wisdom teeth removed.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of East Sarajevo Academic / other |
| Locations | 1 site (Foca, Republika Srpska) |
| Trial ID | NCT06802354 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the efficacy of ozone therapy in minimizing postoperative complications following the extraction of impacted mandibular third molars. Participants will receive ozone treatment after surgery and will be monitored for pain, swelling, and mouth opening over a week, alongside assessments of wound healing and quality of life. The study aims to determine whether ozone can effectively reduce complications and improve recovery outcomes compared to a placebo. All procedures will adhere to ethical guidelines and informed consent will be obtained from participants.
Who should consider this trial
Good fit: Ideal candidates are healthy adults over 18 with bilaterally impacted mandibular third molars classified as impaction index II B.
Not a fit: Patients with contraindications to ozone therapy or those with recent corticosteroid or antibiotic use may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could significantly reduce pain and complications for patients undergoing wisdom tooth extraction.
How similar studies have performed: While ozone therapy is a novel approach in this context, similar studies have shown promising results in other areas of medicine.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients over 18 years * Patients with bilaterally impacted mandibular third molars classified as impaction index II B * Patients in good general health (based on the ASA classification as ASA I and ASA II). Exclusion Criteria: * Contraindications for ozone application (pregnancy, hyperthyroidism, favism, anemia, myasthenia, bleeding disorders, alcohol intoxication, myocardial infarction, pacemaker, allergy to ozone) * Patients who have used corticosteroid and antibiotic therapy in the last three months prior to inclusion in the study * Patients with signs of local inflammation in the oral cavity * Female patients during pregnancy and breastfeeding.
Where this trial is running
Foca, Republika Srpska
- University of East Sarajevo, Faculty of Medicine — Foca, Republika Srpska, Bosnia and Herzegovina (Recruiting)
Study contacts
- Study coordinator: Jelena Krunic, Professor
- Email: jelena.krunic@ues.rs.ba
- Phone: +38758210420
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.