Using Oxybutynin to Treat Bladder Pain After Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of transdermal oxybutynin compared to oral oxybutynin in managing bladder pain and urgency following bladder surgery in children aged four to eight. The study will involve patients who require an indwelling bladder catheter post-surgery, assessing the pain relief provided by each method of administration. Given the limitations of oral oxybutynin due to poor bioavailability and side effects, the trial seeks to determine if the transdermal patch can offer superior outcomes. The results could provide valuable insights into postoperative care for pediatric patients undergoing bladder surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients who will undergo bladder surgery that requires an indwelling bladder catheter after surgery.
* Age Range: Four to 8 years of age are eligible for the study.

Exclusion Criteria:

* Patients who have had prior bladder surgery.
* Patients who have neurologic disease that could impair bladder sensation.
* Patients who are already taking antimuscarinic or antispasmodic medications.
* Patients with glaucoma, any neurologic disease, dementia, impaired mentation or disorder of the central nervous system.
* Patients taking any medication that affects the central nervous system such as antidepressant, anxiolytic or antipsychotic medications.
* Less than four years of age cannot have the transdermal patch due to fixed dose. Over 8 years of age: less than 5% of our patients, who undergo this surgery, are over 8 years of age and is usually a rare adolescent. Data in an older cohort may confuse the results since they respond differently to bladder surgery due to larger incision and longer hospital stay with a catheter.

Where it's running

• University of California Davis Medical Center (UCDMC)
  Sacramento, California, United States Recruiting

Study contacts

• Principal investigator: Eric A Kurzrock, MD — UC Davis Health Center
• Study coordinator: Anjali Vij, BS
• Email: avij@ucdavis.edu
• Phone: 9167345173

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.