Using oscillometry and FeNO to improve primary care diagnosis of asthma and COPD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with suspected asthma (≥18 years) or suspected COPD (≥40 years) who have no prior diagnosis and meet exclusion criteria will undergo oscillometry, FeNO testing, and standard spirometry where feasible. Test results obtained in the primary care/research sites will be compared with specialist clinical diagnosis and spirometry-based criteria to measure diagnostic accuracy. The observational protocol collects diagnostic data at sites in Buenos Aires, Mendoza, and Alexandria without altering routine clinical management. Patients with recent inhaled or oral corticosteroid use or other conditions that affect lung function are excluded to reduce confounding.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients are eligible to be included in the study if all the following criteria apply and after providing written informed consent:

Suspected asthma (asthma group)

1. Patients ≥ 18 years old or with legal age of consent in the jurisdiction in which the study is taking place, at the time of signing the ICF.
2. Patients presenting with symptoms of wheezing, cough, chest tightness, shortness of breath, but without a clinically confirmed diagnosis of asthma.

Suspected COPD (COPD group)

1. Patients ≥ 40 years old at the time of signing the ICF.
2. Patients presenting with symptoms of dyspnea, chronic cough or sputum production, but without a clinically confirmed diagnosis of COPD.

Exclusion Criteria:

Patients are excluded from the study if any of the following criteria apply:

1. Prior diagnosis of COPD or asthma.
2. Use of ICS in the last 6 months or use of oral corticosteroids in the last 3 months.
3. Any diseases that influence lung function result such as lung cancer, pneumonia, active pulmonary tuberculosis, pulmonary embolism, and interstitial lung disease.
4. Any history of recent surgery that affects lung function results, including but not limited to thoracotomy surgery, pneumothorax surgery, and thoracic drainage.
5. Contraindication to spirometry or oscillometry test, or allergy to bronchodilator.
6. Currently pregnant or breast-feeding women.
7. If the investigator judges that the patient is unlikely to comply with study procedures, restrictions, and requirements.

Where it's running

• Research Site
  Buenos Aires, Argentina Recruiting
• Research Site
  Medoza, Argentina Recruiting
• Research Site
  Ho Chi Minh City, Vietnam Recruiting
• Research Site
  Alexandria, Egypt Not yet recruiting
• Research Site
  El Waili, Egypt Not yet recruiting
• Research Site
  Monterrey, Mexico Not yet recruiting

Study contacts

• Study coordinator: AstraZeneca Clinical Study Information Center
• Email: information.center@astrazeneca.com
• Phone: 1-877-240-9479

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Asthma and COPD among workers at Navanakorn Industrial Zone in Thailand

  This project will test how common asthma and COPD are among adult workers at the Navanakorn Industrial Zone by asking about breathing symptoms and doing lung function (spirometry) tests.

  Recruiting Thammasat University · Pathum Thani, Changwat Pathum Thani · NCT07383896

• Using smartphone technology to evaluate airway conditions

  This study is testing if smartphone technology can help check lung health and spot breathing problems in both healthy people and those with asthma or COPD.

  Recruiting at 2 sites Indiana University · Indianapolis, Indiana and 1 other locations · NCT06512064

• Identifying and treating undiagnosed asthma or COPD in Canadians

  This study is trying to find Canadians who might have asthma or COPD without knowing it and see if getting diagnosed and treated early can improve their quality of life.

  Recruiting at 6 sites Ottawa Hospital Research Institute · Hamilton, Ontario and 5 other locations · NCT06392776

• Understanding muscle loss in patients with chronic lung diseases

  This study looks at how muscle loss affects people with chronic lung diseases like COPD and ILD to see how common it is and how it relates to their overall health.

  Recruiting Taichung Veterans General Hospital · Taichung · NCT06280443

• Understanding immune profiles in healthy and diseased lungs

  This study is trying to understand how the immune system works in healthy lungs compared to those with airway diseases like COPD and asthma by looking at samples from both groups.

  Recruiting Guy's and St Thomas' NHS Foundation Trust · London, London · NCT06144476

• Assessing diaphragm function in patients with respiratory diseases

  This study is testing how well the diaphragm works in people with respiratory diseases to see if it affects their breathing difficulties and overall health.

  Recruiting RWTH Aachen University · Aachen, North Rhine-Westphalia · NCT05903001

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.