Using oral dydrogesterone to support pregnancy in natural cycle frozen embryo transfers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized double-blinded controlled trial aims to evaluate the effectiveness of oral dydrogesterone in increasing live birth rates during natural frozen embryo transfer (FET) cycles. Women undergoing FET at the University of Hong Kong-Queen Mary Hospital will be randomly assigned to receive either oral dydrogesterone or a placebo for two weeks following ovulation. The study will monitor the outcomes of these treatments to determine if dydrogesterone provides a significant benefit in supporting pregnancy. The trial focuses on women under 43 years of age who are undergoing FET with thawed embryos.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age of women \<43 years at the time of stimulated IVF
* Replacing early cleavage embryos or blastocysts after thawing

Exclusion Criteria:

* Requiring hormonal replacement cycles
* Use of donor oocytes or embryos
* Undergoing preimplantation genetic testing
* Presence of hydrosalpinx not corrected surgically prior to FET
* Refusal to join the study

Where it's running

• Department of Obstetrics and Gynaecology
  Hong Kong, Hong Kong, China Recruiting

Study contacts

• Principal investigator: Ernest HY Ng, MD — The University of Hong Kong
• Study coordinator: Ernest HY Ng, MD
• Email: nghye@hku.hk
• Phone: 852-28553400

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.