Using Optical Coherence Tomography Angiography to Study Neurological Diseases
Optical Coherence Tomography Angiography in Neurological Disease: A Pilot Study
This study is testing if a special eye imaging technique can help spot signs of neurological diseases like stroke in patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Texas Southwestern Medical Center Academic / other |
| Locations | 1 site (Dallas, Texas) |
| Trial ID | NCT06797765 on ClinicalTrials.gov |
What this trial studies
This observational study utilizes Optical Coherence Tomography Angiography (OCTA), a non-invasive imaging technique, to examine the neurovascular structures of the eye in patients with various neurological conditions. The study aims to gather preliminary data on the effectiveness of OCTA as a screening tool for conditions such as stroke and intracranial hemorrhage. By comparing OCTA imaging parameters between patients with neurological illnesses and healthy controls, the research seeks to establish a foundation for future investigations in this area.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older with specific neurological conditions or healthy individuals without major neurological or cardiovascular diseases.
Not a fit: Patients who are pregnant, non-English speaking, or have severe physical limitations that prevent them from participating will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding and diagnosis of neurological diseases through improved imaging techniques.
How similar studies have performed: While previous studies have shown promise for OCTA in stroke screening, the application of this technology to other neurological conditions remains largely untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or older * Patient admitted to the neuroscience intensive care unit with a diagnosis of: subarachnoid hemorrhage, intracerebral hemorrhage, intracranial aneurysm (ruptured or unruptured), intracranial vascular malformation, ischemic stroke, seizure disorder, intracranial infection, intracranial tumor(s), inflammatory demyelinating disease, traumatic brain injury and/or neuromuscular respiratory failure OR subjects from the community without major neurologic, cardiovascular, pulmonary or metabolic disease Exclusion Criteria: * Pregnancy * Non-English speaking * GCS motor score less than 6 (i.e. must be able to follow commands) * Temporary or permanent physical limitation that renders the patient unable to sit up and look inside OCTA device
Where this trial is running
Dallas, Texas
- UT Southwestern Medical Center — Dallas, Texas, United States (Recruiting)
Study contacts
- Study coordinator: Noah Jouett, DO, PhD
- Email: noah.jouett@utsouthwestern.edu
- Phone: 214-645-7011
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.