Using optic nerve head strain to predict glaucoma progression
Optic Nerve Head Strain as Biomarker for Glaucoma
This study is testing if pictures of the optic nerve can help predict how quickly glaucoma gets worse in people who already have the condition.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 130 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | Johns Hopkins University Academic / other |
| Locations | 1 site (Baltimore, Maryland) |
| Trial ID | NCT06240312 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate whether images of the optic nerve head taken at two different eye pressures can provide strain estimates that predict the progression of glaucoma. Existing glaucoma patients and suitable control adults will undergo imaging using an FDA-approved optical coherence tomography instrument. The biomechanical strain estimates obtained will be compared to visual field and retinal nerve fiber layer measurements over time. The goal is to establish a biomarker that correlates baseline strain and its changes with the rate of glaucoma damage progression.
Who should consider this trial
Good fit: Ideal candidates for this study are existing glaucoma patients receiving care at Johns Hopkins.
Not a fit: Patients who are unable to perform imaging, illiterate, hearing impaired, or non-English speakers may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a new biomarker for predicting glaucoma progression, allowing for earlier and more tailored interventions.
How similar studies have performed: While the approach of using biomechanical strain as a biomarker is innovative, similar studies have not been widely reported, making this a novel investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Existing glaucoma patients of Johns Hopkins Exclusion Criteria: * Inability to perform imaging * illiterate * hearing impaired * non-English speakers
Where this trial is running
Baltimore, Maryland
- Johns Hopkins University — Baltimore, Maryland, United States (Recruiting)
Study contacts
- Principal investigator: Harry Quigley — Johns Hopkins School of Medicine
- Study coordinator: Harry A Quigley
- Email: hquigley@jhmi.edu
- Phone: 4109556051
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.