Using Ondansetron to Prevent Pancreatitis After ERCP

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the safety and efficacy of ondansetron in preventing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis, a common complication that can lead to significant health issues. The study involves administering either ondansetron or a placebo to patients undergoing ERCP for suspected pancreato-biliary disorders. Participants will be monitored for the occurrence of pancreatitis following the procedure, with the aim of determining if ondansetron can effectively reduce this risk. The trial is designed for patients over 18 years old who meet specific health criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age more than 18 years old.
2. Gender: Males and Females
3. Patients with suitable indications for ERCP due to suspected pancreato-biliary disorders.
4. Blood amylase and lipase levels before ERCP are within the normal limits.

Exclusion Criteria:

1. Age of less than18 years.
2. Uncontrolled diabetes mellitus (DM)
3. Severe bleeding tendency
4. Impaired renal function (serum creatinine \> 2 mg/dL), (creatinine clearance \<30 ml/min)
5. Patients with severe heart disease.
6. Subjects who underwent prior biliary or pancreatic sphincterotomy or dilatation or stenting of either duct.
7. Currently pregnant or nursing
8. Admission due to established pancreatitis before ECRP
9. Unwillingness to undergo ERCP.
10. Previously documented allergy to ondansetron.

Where it's running

• Tanta Unuversity
  Tanta, Egypt Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.