Using OCT to assess corneal health in Fuchs' Dystrophy
Official title: Evaluating Corneal Edema in Fuchs' Endothelial Dystrophy Using Optical Coherence Tomography
Run by Oregon Health and Science University · NCT04258787 · Data updated 2026-11-12
This study is testing a new way to measure corneal swelling in people with Fuchs' dystrophy to see how it affects their vision after surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Oregon Health and Science University Academic / other |
| Locations | 1 site (Portland, Oregon) |
| Status | Recruiting |
| Started | June 26, 2020 |
| Main results expected | June 2027 |
| Study ends | June 2028 |
| Registry record updated | September 9, 2025 |
| Trial ID | NCT04258787 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals with damaged or diseased corneal endothelium due to Fuchs' dystrophy or pseudophakic bullous keratopathy who can commit to study visits.
✕Probably not a fit
Patients who have undergone prior endothelial keratoplasty or have other significant ocular conditions that may complicate treatment are unlikely to benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study utilizes optical coherence tomography (OCT) technology to measure corneal edema in patients with Fuchs' endothelial dystrophy and pseudophakic bullous keratopathy. The goal is to quantify the extent of corneal swelling and predict changes in vision following surgical interventions. Participants will undergo regular study visits to monitor their condition and the effects of treatment. The study aims to enhance understanding of corneal health in these conditions.
Why it matters
Potential benefit: If successful, this study could improve the management and treatment outcomes for patients with Fuchs' dystrophy and related conditions.
How similar studies have gone: While the use of OCT in corneal assessments is established, this specific application in Fuchs' dystrophy and pseudophakic bullous keratopathy is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Damaged or diseased corneal endothelium from Fuchs' or PBK * Willingness to commit to required study visits Exclusion Criteria: * Prior Endothelial Keratoplasty (EK) or any other surgery except uncomplicated cataract surgery * Presence of a condition that increases the probability for treatment failure (e.g., heavily vascularized cornea, uncontrolled uveitis) * Other primary endothelial dysfunction conditions (e.g., posterior polymorphous corneal dystrophy and congenital hereditary corneal dystrophy, iridocorneal endothelial syndrome) * Central sub-epithelial or stromal scarring that could impact post-operative clarity assessment * Peripheral anterior synechiae in the angle greater than 3 clock hours * Hypotony * Uncontrolled glaucoma * Visually significant optic nerve or macular pathology
Where it's running
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Oregon Health & Science University
Portland, Oregon, United States Recruiting
Study contacts
- Principal investigator: Winston Chamberlain, MD, PhD — Oregon Health and Science University
- Study coordinator: Humberto Martinez, COT
- Email: martinhu@ohsu.edu
- Phone: 503-494-7712
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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EO2002 therapy for corneal edema due to endothelial dysfunction
This trial tests whether a single intracameral injection of EO2002 cells can improve vision and reduce corneal thickness in adults with corneal edema from endothelial dysfunction.
-
Assessing the safety of EO2002 injections for corneal conditions
This study is testing if EO2002 injections are safe for people with corneal conditions like Fuchs' dystrophy or pseudophakic bullous keratopathy.
-
PVEK corneal implant to treat corneal swelling
This study will test a PVEK tissue‑engineered corneal implant to see if it is safe and helps people with corneal swelling from Fuchs' endothelial dystrophy or pseudophakic bullous keratopathy who need endothelial keratoplasty.
-
Understanding Fuchs' Endothelial Corneal Dystrophy and its Genetic Links
This study is trying to understand how Fuchs' Endothelial Corneal Dystrophy affects younger people with a genetic link to the condition by using advanced imaging to track changes over time.
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Observing outcomes of posterior lamellar keratoplasty for eye conditions
This study looks at how well two types of eye surgeries for conditions like Fuchs' dystrophy and bullous keratopathy work in helping patients see better over time.
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OPTIMISE — safer steroid plans after DMEK cornea transplant
This study tests whether using a milder steroid eye drop plan or stopping steroids earlier after DMEK can still prevent graft rejection while reducing the risk of high eye pressure in adults receiving corneal transplants.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.