Using NovoMatrix for treating gum recession
Official title: Safety and Efficacy of NovoMatrix in Gingival Recession Coverage /A Pilot Clinical and Histological Case Series/
Run by Semmelweis University · NCT06409468 · Data updated 2026-11-12
This study is testing whether a new treatment called NovoMatrix can help people with gum recession improve their gum health and appearance after surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 70 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Semmelweis University Academic / other |
| Locations | 1 site (Budapest) |
| Status | Recruiting |
| Started | May 5, 2024 |
| Main results expected | December 15, 2025 |
| Study ends | December 15, 2025 |
| Registry record updated | April 4, 2025 |
| Trial ID | NCT06409468 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals aged 20-70 with multiple Miller Class I or II gingival recessions who are in good health and maintain good oral hygiene.
✕Probably not a fit
Patients with significant untreated periodontal disease, chronic inflammation, or those who have previously failed autogenous grafts may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study involves twenty patients aged 20-70 with multiple Miller Class I or II buccal gingival recessions seeking treatment for gum recession coverage. Participants will undergo surgery using a subperiostal tunnel technique in conjunction with NovoMatrix, following established dental practice guidelines. Five patients will also have a single rooted tooth removed for histological sampling at the six-month mark. The study aims to assess the effectiveness of this approach in improving gum health and aesthetics.
Why it matters
Potential benefit: If successful, this treatment could enhance gum coverage and improve oral health for patients with gingival recession.
How similar studies have gone: While similar approaches have been explored, this specific use of NovoMatrix in conjunction with the subperiostal tunnel technique is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or female, between 20-70 years of age, who request gingival augmentation or recession coverage. * Subjects who are willing to sign an informed consent, participate and return for follow-up visits. * Subjects without significant medical history and currently not on medications that might complicate treatment outcomes. * Subjects demonstrating good oral hygiene (FMPS, FMBS less than 20%). Exclusion Criteria: * Subjects who do not meet all the inclusion criteria or who will not cooperate with the protocol schedule. * Subjects who received and failed a previously placed autogenous graft. * Subjects who have significant untreated periodontal disease, caries, infection or chronic inflammation in the oral cavity within two adjacent tooth positions of the clinical trial area. * Subjects who have used nicotine-containing products within 3 weeks prior to surgery. * Subjects who are insulin-dependent diabetic or if their Hgb1c levels \> 6.5%. * Subjects who have had a history of malignancy within the past 5 years (except for basal or squamous cell carcinoma of the skin or in situ cervical carcinoma). * Subjects who are nursing or pregnant. * Subjects who are presently taking medications (except estrogen/progesterone therapy) or those who are undergoing treatment that in known to have an effect on bone turnover. * Subjects who have diseases that affect bone metabolism (excluding idiopathic osteoporosis). * Subjects with a history of an autoimmune disease, documented allergy or multiple allergies to any component of the agents used in this study. * Acutely infected mucogingival defect site.
Where it's running
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Semmelweis University, Faculty of Dentistry
Budapest, Hungary Recruiting
Study contacts
- Principal investigator: Péter Windisch, Profesor — Semmelweis University
- Study coordinator: Bálint Molnár, DMD
- Email: molbal81@gmail.com
- Phone: 0613185222
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Palatal Wound Healing After Free Gingival Graft in Diabetic Patients
This study tests palatal wound healing after a free gingival graft in adults with and without diabetes to see if diabetes affects healing and what factors are linked to outcomes.
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Oral Mucosa Healing After Gum Recession Treatment in Diabetic People
This study tests how gingival recession treatment heals in people with diabetes compared with people without diabetes.
-
CAF versus TCAF with connective tissue grafts for multiple maxillary gum recessions
This comparison will test whether coronally advanced flap (CAF) or tunneled coronally advanced flap (TCAF), each combined with a connective tissue graft, provides better root coverage for adults with multiple gum recessions in the upper jaw.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.