Using norepinephrine to improve blood pressure in patients with hemorrhagic shock
Is Low Dose Norepinephrine Effective in Preperiod of Hypotensive Resuscitation in Hemorrhagic Shock?
NA · Tanta University · NCT06311903
This study is testing if giving low doses of norepinephrine can help improve blood pressure and blood flow in patients with severe bleeding and shock.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Tanta University (other) |
| Locations | 1 site (Tanta, El-Gharbia) |
| Trial ID | NCT06311903 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of low doses of norepinephrine during the preperiod of hypotensive resuscitation in patients experiencing hemorrhagic shock. Hemorrhagic shock is a critical condition that can lead to death following trauma, and this research aims to explore new fluid resuscitation strategies that include hypotensive and delayed resuscitation methods. The study will compare the outcomes of patients receiving low versus high doses of norepinephrine to maintain target arterial blood pressure and improve microcirculation. The findings could provide insights into optimizing treatment protocols for managing severe bleeding and shock.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who are experiencing hemorrhagic shock.
Not a fit: Patients with cardiac arrest, severe brain or spinal injuries, or those who are pregnant will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance survival rates and recovery outcomes for patients suffering from hemorrhagic shock.
How similar studies have performed: While the use of norepinephrine in resuscitation has been recommended in guidelines, this specific approach is novel and has not been extensively tested in similar studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years old. * Both sexes. * Patients with hemorrhagic shock Exclusion Criteria: * Patients with cardiac arrest at admission. * Severe brain. * Spinal injury (because of different target blood pressures). * Death due to hemostatic failure within 6 h of admission. * Pregnancy.
Where this trial is running
Tanta, El-Gharbia
- Tanta University — Tanta, El-Gharbia, Egypt (RECRUITING)
Study contacts
- Study coordinator: Rabab M Mohamed, MD
- Email: rabmoh_30@outlook.com
- Phone: 00201069122935
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Norepinephrine, Hemorrhagic Shock, Hypotensive Resuscitation