Using non-invasive tools to monitor brain health after surgery
Official title: Transcranial Doppler, Optic Nerve Envelope Diameter and Quantitative Pupillometry Measurements in Postoperative Resuscitation Neurosurgery
Run by Centre Hospitalier Universitaire de la Réunion · NCT05843214 · Data updated 2026-11-12
This study is testing non-invasive tools to see if they can help monitor brain health and catch any early problems in French-speaking patients after they have surgery on their brain.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 230 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de la Réunion Academic / other |
| Locations | 1 site (Saint-Pierre) |
| Status | Recruiting |
| Started | February 10, 2023 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | September 11, 2026 |
| Trial ID | NCT05843214 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are French-speaking patients scheduled for regulated intracranial surgery more than 48 hours in advance.
✕Probably not a fit
Patients with chronic subdural hematoma, isolated cerebral endovascular procedures, or specific ocular conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study evaluates the effectiveness of non-invasive neuromonitoring tools, including transcranial Doppler, optic nerve envelope diameter measurement, and quantitative pupillometry, in patients undergoing controlled intracranial surgery. The aim is to detect early signs of postoperative neurological deterioration by monitoring various physiological parameters. The study focuses on French-speaking patients scheduled for surgery more than 48 hours in advance, ensuring a comprehensive assessment of their neurological status during recovery.
Why it matters
Potential benefit: If successful, this study could enhance the early detection of neurological complications in patients after brain surgery, potentially improving patient outcomes.
How similar studies have gone: While the use of these non-invasive monitoring tools is common in acute brain injury management, this specific application in controlled intracranial surgery is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Regulated intracranial surgery: scheduled \> 48 hours * French-speaking patient * No opposition from the patient or a relative when the patient is unable to consent Exclusion Criteria: * Chronic subdural haematoma * Isolated cerebral endovascular procedure * Stereotactic biopsy * Scheduled ventriculoperitoneal shunt or isolated ventriculocisternostomy * Specific non-inclusion criteria for quantitative pupillometry: known pupillary abnormalities, glaucoma, cataract surgery and any ocular surgery.
Where it's running
-
CHU de la Réunion
Saint-Pierre, Reunion Recruiting
Study contacts
- Principal investigator: Romain ASMOLOV, MD — CHU de la Réunion
- Study coordinator: Romain ASMOLOV, MD
- Email: <romain.asmolov@chu-reunion.fr>
- Phone: 02 62 35 90 00
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.