Using nivolumab with AVD for advanced Hodgkin lymphoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial evaluates the effectiveness and safety of a flat-dose nivolumab (40 mg) combined with AVD chemotherapy in patients with newly diagnosed advanced classic Hodgkin lymphoma. Participants will undergo 6 cycles of treatment, with interim and end-of-treatment PET/CT scans to assess their response. The interim scans will not influence clinical decisions but will help identify response predictors after the initial therapy. If patients show only a partial metabolic response after 6 cycles, they may receive radiation therapy as part of their treatment plan.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Newly-diagnosed histologically verified advanced stage (IIB-IV as per GHSG) classic Hodgkin lymphoma
2. No past history of autoimmune disease
3. Age \> 18 years
4. Ejection fraction \> 50%
5. ECOG 0-4

Exclusion Criteria:

1. Organ failure (e.g. creatinine \> 2x ULN; ALT or AST \> 5x ULN; bilirubin \> 2x ULN; hemodynamic instability; respiratory failure \> Grade 1)
2. Uncontrolled infection
3. Pregnancy
4. Inability to sign informed consent

Where it's running

• P. Hertsen Moscow Oncology Research Institute (MORI) for administrative and economic work - the branch of the FSBI "National Medical Research Radiological Centre" (NMRRC) of the Ministry of Health of the Russian Federation
  Moscow, Russia Recruiting

Study contacts

• Study coordinator: Mobil Akhmedov, MD, PhD
• Email: mobilakhmedov@gmail.com
• Phone: 79261802399

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.