Using nimodipine to protect nerves during vestibular schwannoma surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effects of nimodipine, a medication known for its neuroprotective properties, when applied directly to the facial and cochlear nerves during the surgical removal of vestibular schwannomas. It is a prospective, randomized, placebo-controlled, double-blinded trial aimed at determining whether nimodipine can reduce the risk of postoperative facial paralysis and hearing loss. Participants will be randomly assigned to receive either nimodipine or a placebo during their surgery, with outcomes assessed postoperatively.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \> 18a
* Vestibular schwannoma with maximum diameter of 10-25mm on MRI
* Pre-operative audiogram
* Informed consent

Exclusion Criteria:

* Contraindication for nimodipine application
* Vestibularis schwannoma diameter \<10mm or \>25mm on MRI

Where it's running

• Medical University of Vienna
  Vienna, Austria Recruiting

Study contacts

• Principal investigator: Dorian Hirschmann, MD — University Clinic of Neurosurgery
• Study coordinator: Dorian Hirschmann, Dr
• Email: dorian.hirschmann@meduniwien.ac.at
• Phone: +434040025780

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• 3D MRI Elastography to Peek at Vestibular Schwannoma Stiffness and How It Relates to Surgery

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• Vestibular rehabilitation for adults having surgery for a unilateral vestibular schwannoma

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• Testing brain vestibular centers after vestibular schwannoma surgery with MRI

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• Steroids to protect facial nerve function after skull-base surgery for vestibular schwannoma

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• Rehabilitation for patients with vestibular deficits using head impulse testing

  This study is testing a new rehabilitation method using head movement exercises to help people with balance issues from vestibular problems, like vestibular schwannoma, see if it improves their eye and balance function compared to a simple eye movement treatment.

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• Using special MRI to detect inflammation in brain tumors

  This study is testing a special MRI technique that uses a contrast agent to see if it can help doctors spot inflammation in brain tumors like vestibular schwannomas and gliomas.

  Recruiting Northern Care Alliance NHS Foundation Trust · Salford, Greater Manchester · NCT06572475

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.