Using nerve stimulation to treat bladder issues in women with multiple sclerosis
Effect of Transcutaneous Posterior Tibial Nerve Stimulation and Parasacral Transcutaneous Electrical Stimulation on Neurogenic Overactive Bladder Symptoms in Female Patients With Multiple Sclerosis.
NA · Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization · NCT06143397
This study is testing whether two types of nerve stimulation can help women with multiple sclerosis who have overactive bladder symptoms feel better.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 42 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | Female |
| Sponsor | Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization (other) |
| Locations | 1 site (Istanbul) |
| Trial ID | NCT06143397 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of transcutaneous tibial nerve stimulation (TTNS) and parasacral nerve stimulation (PNS) in alleviating overactive bladder symptoms in female patients with multiple sclerosis. Participants will be divided into three groups: those receiving TTNS, those receiving PNS, and a placebo group, all of whom will also undergo behavioral treatment. The study will assess various urinary parameters and quality of life before and after the treatment period, which lasts six weeks with stimulation sessions twice a week. The goal is to compare the outcomes between the treatment groups and the placebo group.
Who should consider this trial
Good fit: Ideal candidates are female patients over 18 years old with multiple sclerosis and overactive bladder symptoms.
Not a fit: Patients with urinary tract infections, diabetes, or other specified exclusions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could significantly improve bladder control and quality of life for women suffering from overactive bladder due to multiple sclerosis.
How similar studies have performed: Previous studies have shown promise in using nerve stimulation techniques for bladder control, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Having symptoms related to overactive bladder (OAB-v8 score ⩾8), * Over 18 years of age * No relapse for at least 1 month * All types of MS, including those with relapses * Female MS patients with an Expanded Disability Status Scale (EDSS) score below 7.0 * Agreeing to participate in the research Exclusion Criteria: * Patients with urinary tract infections * Patients diagnosed with diabetes mellitus * Patients using diuretic drugs or patients with a clean intermittent catheter * Patients with a history of different urological diseases * Patients with heart or brain pacemaker users, those with epilepsy, and patients with language and cognitive limitations * Patients who are pregnant or in the postpartum period * Lack of activity performance for 2 weeks (regardless of which group)
Where this trial is running
Istanbul
- Prof.Dr.Cemil Taşcıoğlu Şehir Hastanesi — Istanbul, Turkey (RECRUITING)
Study contacts
- Study coordinator: Büşra Aydın Erkılıç, MSc
- Email: bsrr.aydinn@gmail.com
- Phone: +90 5062214052
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Multiple Sclerosis, Overactive Bladder Syndrome